FlyBase Allele Report: Dmel\Nf1[E2]

General Information

Symbol

Dmel\Nf1^E2

Species

D. melanogaster

Name

FlyBase ID

FBal0197115

Feature type

allele

Associated gene

Dmel\Nf1

Associated Insertion(s)

Carried in Construct

Also Known As

dNf1^E2

Key Links

Genomic Maps

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Help me choose

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Walker et al., 2006)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point_mutation

3R:25,984,852..25,984,852 [+]

Nucleotide change:

C25984852T

Amino acid change:

Reported amino acid change:

Q370term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Walker et al., 2006)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Amino acid replacement: Q370term.

(Walker et al., 2006)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurofibromatosis

CEA

(Walker et al., 2006)

CEA with Nf1^E1

(Walker et al., 2006)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurofibromatosis

is ameliorated by Raf¹²

(Walker et al., 2006)

is ameliorated by Ras85D^unspecified

(Walker et al., 2006)

is ameliorated by rl¹

(Walker et al., 2006)

is ameliorated by vap^UAS.Tag:MYC

(Walker et al., 2006)

is ameliorated by jeb^weli

(Walker et al., 2013)

is ameliorated by car¹

(Walker et al., 2013)

is ameliorated by cnk^XE-385

(Walker et al., 2013)

is ameliorated by elav¹

(Walker et al., 2013)

is ameliorated by amx^f06362

(Walker et al., 2013)

is ameliorated by Rab9^{S26N.UASp.YFP}

(Walker et al., 2013)

is exacerbated by nAChRα6^DAS2

(Walker et al., 2013)

is ameliorated by car^Δ146

(Walker et al., 2013)

is ameliorated by dnc^KK108541

(Walker et al., 2013)

is ameliorated by jeb^KK111857

(Walker et al., 2013)

is ameliorated by Dap160^Δ1

(Walker et al., 2013)

is ameliorated by Rab9^KK109041

(Walker et al., 2013)

is exacerbated by Cul3^gft2

(Walker et al., 2013)

is ameliorated by Dap160^KK102297

(Walker et al., 2013)

is ameliorated by Dap160^Δ2

(Walker et al., 2013)

is exacerbated by nAChRα6^KG05852

(Walker et al., 2013)

is exacerbated by Pka-C1^B3

(Walker et al., 2013)

is ameliorated by cnk^E-2083

(Walker et al., 2013)

is NOT ameliorated by Ret^K805A.UAS

(Walker et al., 2013)

is ameliorated by dnc^ML

(Walker et al., 2013)

is ameliorated by NAAT1^KK112890

(Walker et al., 2013)

is exacerbated by Pka-C1^BG02142

(Walker et al., 2013)

is ameliorated by Mmus\Prkaca^act.2xUAS

(Walker et al., 2013)

is exacerbated by nAChRα6^DAS1

(Walker et al., 2013)

is ameliorated by Alk⁸

(Walker et al., 2013)

is ameliorated by dor⁸

(Walker et al., 2013)

is ameliorated by Dsor1^LH110

(Walker et al., 2013)

is ameliorated by amx^GD1168

(Walker et al., 2013)

is ameliorated by elav^G0031

(Walker et al., 2013)

is exacerbated by Pka-C1⁰⁶³⁵³

(Walker et al., 2013)

is ameliorated by HERC2^KK100181

(Walker et al., 2013)

is ameliorated by CCKLR-17D1^KK108482

(Walker et al., 2013)

is ameliorated by Mmus\Prkaca^act.3xUAS

(Walker et al., 2013)

is ameliorated by Mmus\Prkaca^mC.UAS

(Walker et al., 2013)

is ameliorated by dnc^M14

(Walker et al., 2013)

is ameliorated by dnc¹

(Walker et al., 2013)

is ameliorated by Dsor1^KK102276

(Walker et al., 2013)

is ameliorated by cnk^KK109209

(Walker et al., 2013)

is ameliorated by Mmus\Prkaca^act.4xUAS

(Walker et al., 2013)

is ameliorated by Dsor1^GD9123

(Walker et al., 2013)

is ameliorated by Alk^KK102942

(Walker et al., 2013)

is ameliorated by Hs3st-B^KK108793

(Walker et al., 2013)

is ameliorated by Alk⁹

(Walker et al., 2013, Gouzi et al., 2011)

is ameliorated by Alk¹

(Gouzi et al., 2011)

is ameliorated by Alk^{EC.UAS.Tag:MYC}

(Gouzi et al., 2011)

is ameliorated by Alk^GD42

(Gouzi et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | adult stage (with Nf1^E1)

(Gouzi et al., 2011)

abnormal learning | adult stage | dominant

(Gouzi et al., 2011)

abnormal neuroanatomy | larval stage

(Tsai et al., 2012)

abnormal neuroanatomy | larval stage (with Nf1^E1)

(Tsai et al., 2012)

abnormal neuroanatomy | third instar larval stage

(Walker et al., 2013)

abnormal neurophysiology | larval stage

(Tsai et al., 2012)

abnormal neurophysiology | larval stage (with Nf1^E1)

(Tsai et al., 2012)

abnormal size | dominant | pupal stage

(Gouzi et al., 2011)

abnormal size | pupal stage (with Nf1^E1)

(Gouzi et al., 2011)

decreased body size | larval stage

(Walker et al., 2013)

decreased body size | pupal stage

(Walker et al., 2013, Tsai et al., 2012, Walker et al., 2006)

decreased body size | pupal stage (with Nf1^P2)

(Walker et al., 2006)

decreased cell size | adult stage

(Gouzi et al., 2011)

Phenotype Manifest In

NMJ bouton | increased number | third instar larval stage

(Walker et al., 2013)

NMJ bouton | larval stage | increased number

(Tsai et al., 2012)

NMJ bouton | larval stage | increased number (with Nf1^E1)

(Tsai et al., 2012)

pupa

(Walker et al., 2006)

pupa (with Nf1^P2)

(Walker et al., 2006)

wing

(Gouzi et al., 2011, Walker et al., 2006)

Detailed Description

Statement

Reference

Mutant larvae ingest similar amounts of food as control larvae, but are smaller in size. As occurs in wild type, the mutant larvae do not wander from a food source.

The timing of pupariation is normal in Nf1^E1/Nf1^E2 animals, but they show an approximately 25% weight reduction compared to controls at the end of the larval stage.

Nf1^E1/Nf1^E2 do not show altered longevity compared to controls.

Mutant third instar larvae show an increase in mean number of boutons per neuromuscular junction compared to controls.

(Walker et al., 2013)

Bouton number per muscle area is significantly increased compared to wild type at the neuromuscular junction (NMJ) in homozygous and Nf1^E1/Nf1^E2 larvae.

The amplitude of the evoked junctional potential (EJP) at the NMJ is significantly increased in homozygous larvae compared to wild type, while the amplitude of the spontaneous mEJP is unaffected. The quantal content at the mutant NMJs is thus increased compared to wild type.

The amplitude of the evoked junctional potential (EJP) at the NMJ is significantly increased in Nf1^E1/Nf1^E2 larvae compared to wild type.

(Tsai et al., 2012)

Homozygous Nf1^E2 pupae are smaller than wild type. Small pupae are also seen in heterozygotes. Both homozygous and heterozygous adult flies exhibit associative olfactory learning defects.

Nf1^E2/Nf1^E1 pupae are smaller than wild type. Adult flies exhibit associative olfactory learning defects.

(Gouzi et al., 2011)

Homozygous pupae are 15-20% smaller than wild-type controls. Heterozygous pupae also show a small but highly significant reduction in length compared to controls.

The surface area of the wing in homozygotes is only 57% that of control flies.

(Walker et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)Exel8034/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by +/Df(2L)BSC188

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2R)BSC639/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2R)Exel6059/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)Exel6024/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)BSC216/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)BSC240/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)Exel7043/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)Exel6025/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)ED800/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)ED1050/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by +/Df(1)ED7229

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)ED1004/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Pka-C1[+]/Pka-C1^BG02142

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Pka-C1[+]/Pka-C1⁰⁶³⁵³

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Pka-C1^B3

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by nAChRα6^DAS1

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by nAChRα6^DAS2

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by nAChRα6^KG05852

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Cul3^gft2

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(1)BSC646/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by +/Df(2L)ED280

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)ED6569/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)ED353/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)ED1305/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)ED108/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, enhanceable by Df(2L)BSC148/+

(Walker et al., 2013)

Nf1^E2 has abnormal size | dominant | pupal stage phenotype, enhanceable by jeb^UAS.cVa/Scer\GAL4^elav-C155

(Gouzi et al., 2011)

NOT Enhanced by

Statement

Reference

Nf1^E2 has decreased body size | pupal stage phenotype, non-enhanceable by Df(1)ED6574/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-enhanceable by Df(1)ED11354/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-enhanceable by Df(2R)BSC154/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-enhanceable by Df(1)ED7261/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-enhanceable by Df(2L)BSC312/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-enhanceable by +/Df(2L)BSC692

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-enhanceable by Df(2L)BSC206/+

(Walker et al., 2013)

Nf1^E2 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by spi¹/spi[+]

(Walker et al., 2013)

Suppressed by

Statement

Reference

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel6291/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC581/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)ED6802/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC658/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC725/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC834/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC823/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel6234/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC763/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC572/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC583/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel6251/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)BSC147/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2L)Exel7038

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)Exel7010/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)BSC256/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2L)Exel7080

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)BSC107/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)BSC105/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)BSC244/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)Exel9064/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)BSC215/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)Exel6045/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC307/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC383/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)Exel7158/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2R)BSC262

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2R)BSC334

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC131/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2R)BSC271

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC152/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC338/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC268/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC429/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC279/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC404/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC777/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2R)BSC158

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC821/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC406/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC264/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2R)Exel7173

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)Exel6065/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)Exel7128/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)Exel7098/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2R)BSC699

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)Exel7124/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC231/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2R)BSC701

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC339/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)Exel7144/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2R)Exel6064

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC199/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(2R)BSC161

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC710/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC656/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)ED447/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel9051/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel7464/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)BSC302/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)Exel6047/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(1)Exel6221

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(1)ED6396

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2L)Exel8041/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel6254/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC533/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel6290/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel9068/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(2R)BSC607/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(1)BSC275

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC719/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel8196/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC589/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Alk⁸

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Alk⁹

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by jeb^weli/jeb[+]

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by cnk[+]/cnk^XE-385

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by cnk[+]/cnk^E-2083

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Dsor1[+]/Dsor1^LH110

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by amx[+]/amx^f06362

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by dnc^M14/dnc[+]

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by dnc^ML/dnc[+]

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by dnc¹

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Dap160[+]/Dap160^Δ1

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Dap160[+]/Dap160^Δ2

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by elav[+]/elav^G0031

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by elav[+]/elav¹

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by car^Δ146

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by car¹

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by dor⁸/dor⁺

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Ras64B.PW/jeb^KK111857

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by jeb^KK111857/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by jeb^KK111857/Scer\GAL4^nSyb.PS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible | partially by Scer\GAL4^repo/jeb^KK111857

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Alk^KK102942/Scer\GAL4^Ras64B.PW

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Alk^KK102942/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Alk^KK102942/Scer\GAL4^nSyb.PS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Ras64B.PW/Dsor1^KK102276

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^nSyb.PS/Dsor1^GD9123

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Ras64B.PW/amx^GD1168

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by amx^GD1168/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by cnk^KK109209/Scer\GAL4^Ras64B.PW

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by cnk^KK109209/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by CCKLR-17D1^KK108482/Scer\GAL4^Ras64B.PW

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by CCKLR-17D1^KK108482/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Dap160^KK102297/Scer\GAL4^Ras64B.PW

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Dap160^KK102297/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Dap160^KK102297/Scer\GAL4^nSyb.PS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Ras64B.PW/Rab9^KK109041

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^C23/Rab9^KK109041

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Act5C.PU/Rab9^{S26N.UASp.YFP}

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^nSyb.PS/Rab9^{S26N.UASp.YFP}

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^C23/Rab9^{S26N.UASp.YFP}

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Dcr-2^UAS.cDa/Scer\GAL4^Ras64B.PW/NAAT1^KK112890

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by NAAT1^KK112890/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^nSyb.PS/NAAT1^KK112890

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Ras64B.PW/HERC2^KK100181

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Ras64B.PW/Hs3st-B^KK108793

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Hs3st-B^KK108793/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Act5C.PU/dnc^KK108541

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Feb36/dnc^KK108541

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Aug21/dnc^KK108541

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Akh.PW/dnc^KK108541

(Walker et al., 2013)

Nf1^E2 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Alk⁹/Alk[+]

(Walker et al., 2013)

Nf1^E2 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by jeb^weli/jeb[+]

(Walker et al., 2013)

Nf1^E2 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by cnk[+]/cnk^XE-385

(Walker et al., 2013)

Nf1^E2 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Df(1)Exel9051/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Aug21/Mmus\Prkaca^act.2xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Akh.PW/Mmus\Prkaca^act.2xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Feb36/Mmus\Prkaca^act.3xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Aug21/Mmus\Prkaca^act.3xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Akh.PW/Mmus\Prkaca^act.3xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Aug21/Mmus\Prkaca^act.4xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Akh.PW/Mmus\Prkaca^act.4xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^Akh.PW/Mmus\Prkaca^mC.UAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel6255/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)ED7294/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel6231/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel6223/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC723/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC310/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(1)BSC866

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel6237/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel9049/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by +/Df(1)BSC626

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC657/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)Exel6241/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC546/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC628/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC706/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC582/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC708/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC755/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC853/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC536/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Df(1)BSC705/+

(Walker et al., 2013)

Nf1^E2 has abnormal size | pupal stage phenotype, suppressible | partially by Alk¹/Alk[+]

(Gouzi et al., 2011)

Nf1^E2 has abnormal learning | adult stage phenotype, suppressible | partially by Alk¹/Alk[+]

(Gouzi et al., 2011)

Nf1^E2 has abnormal size | pupal stage phenotype, suppressible | partially by Alk⁹/Alk[+]

(Gouzi et al., 2011)

Nf1^E2 has abnormal learning | adult stage phenotype, suppressible | partially by Alk⁹/Alk[+]

(Gouzi et al., 2011)

Nf1^E2 has abnormal size | recessive | pupal stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Alk^{EC.UAS.Tag:MYC}

(Gouzi et al., 2011)

Nf1^E2 has abnormal size | recessive | pupal stage phenotype, suppressible | partially by Alk^{EC.UAS.Tag:MYC}/Scer\GAL4^Ras64B.PW

(Gouzi et al., 2011)

Nf1^E2 has abnormal size | recessive | pupal stage phenotype, suppressible | partially by Alk^{EC.UAS.Tag:MYC}/Scer\GAL4^386Y

(Gouzi et al., 2011)

Nf1^E2 has abnormal size | recessive | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Alk^GD42

(Gouzi et al., 2011)

Nf1^E2 has abnormal size | recessive | larval stage phenotype, suppressible | partially by Alk^GD42/Scer\GAL4^Ras64B.PW

(Gouzi et al., 2011)

Nf1^E2 has decreased cell size | adult stage phenotype, suppressible | partially by Alk^GD42/Scer\GAL4^Ras64B.PW

(Gouzi et al., 2011)

Nf1^E2 has abnormal size | recessive | larval stage phenotype, suppressible | partially by Alk^GD42/Scer\GAL4^386Y

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 has abnormal learning | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Alk^{EC.UAS.Tag:MYC}

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 has abnormal learning | adult stage phenotype, suppressible by Alk^{EC.UAS.Tag:MYC}/Scer\GAL4^Ras64B.PW

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 has abnormal learning | adult stage phenotype, suppressible by Alk^{EC.UAS.Tag:MYC}/Scer\GAL4^Alk.38

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 has abnormal learning | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Alk^GD42

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 has abnormal learning | adult stage phenotype, suppressible by Alk^GD42/Scer\GAL4^Ras64B.PW

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 has abnormal learning | adult stage phenotype, suppressible by Alk^GD42/Scer\GAL4^Alk.38

(Gouzi et al., 2011)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible | partially by phl[+]/Raf¹²/Ras85D[+]/Ras85D^unspecified

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible | partially by rl[+]/rl¹/phl[+]/Raf¹²

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^elav-C155/vap^UAS.Tag:MYC

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, suppressible by vap^UAS.Tag:MYC/Scer\GAL4^Ras64B.PW

(Walker et al., 2006)

NOT suppressed by

Statement

Reference

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by InR⁰⁵⁵⁴⁵

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by InR³²⁷

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Df(1)ED6574/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Df(1)ED11354/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Df(2R)BSC154/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Df(1)ED7261/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Df(2L)BSC312/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by +/Df(2L)BSC692

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Df(2L)BSC206/+

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Alk^KK102942/Scer\GAL4^repo

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by CCKLR-17D1^KK108482/Scer\GAL4^repo

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by CCKLR-17D3^GD3431/Scer\GAL4^Ras64B.PW

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by CCKLR-17D3^GD3431/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by CCKLR-17D3^GD3431/Scer\GAL4^repo

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^Ret.PW/Ret^K805A.UAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^repo/NAAT1^KK112890

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by HERC2^KK100181/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^repo/Hs3st-B^KK108793

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^elav.PU/dnc^KK108541

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^Ras64B.PW/dnc^KK108541

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by dnc^KK108541/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by spi¹/spi[+]

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^Feb36/Mmus\Prkaca^act.2xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Mmus\Prkaca^act.2xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^Ras64B.PW/Mmus\Prkaca^act.2xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^C23/Mmus\Prkaca^act.2xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Mmus\Prkaca^act.3xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^Ras64B.PW/Mmus\Prkaca^act.3xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Mmus\Prkaca^act.3xUAS/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Mmus\Prkaca^act.4xUAS

(Walker et al., 2013)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Mmus\Prkaca^act.4xUAS/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 has abnormal size | recessive | larval stage phenotype, non-suppressible by Scer\GAL4^ey-OK107/Alk^{EC.UAS.Tag:MYC}

(Gouzi et al., 2011)

Nf1^E2 has abnormal size | recessive | larval stage phenotype, non-suppressible by Scer\GAL4^ey-OK107/Alk^GD42

(Gouzi et al., 2011)

Nf1^E2 has abnormal size | recessive | larval stage phenotype, non-suppressible by Alk^{EC.UAS.Tag:MYC}/Scer\GAL4^CCAP.PP

(Gouzi et al., 2011)

Nf1^E2 has abnormal size | recessive | larval stage phenotype, non-suppressible by Scer\GAL4^CCAP.PP/Alk^GD42

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 has abnormal learning | adult stage phenotype, non-suppressible by Scer\GAL4^c747/Alk^{EC.UAS.Tag:MYC}

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 has abnormal learning | adult stage phenotype, non-suppressible by Scer\GAL4^c747/Alk^GD42

(Gouzi et al., 2011)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Df(3L)GN34/+

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by +/Df(3L)GN19

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by vap^UAS.Tag:MYC/Scer\GAL4^repo

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^elav-C155/RasGAP1^UAS.cWa

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^Ras64B.PW/RasGAP1^UAS.cWa

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Scer\GAL4^repo/RasGAP1^UAS.cWa

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Ras85D[+]/Ras85D^unspecified

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Rgl^BG02025

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Rala^unspecified

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Pi3K21B^EY06407

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Ras64B^unspecified/Ras85D[+]/Ras85D^unspecified

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Dsor1[+]/Ras85D[+]/Ras85D^unspecified/Dsor1^S-1221

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Ras64B^unspecified/Dsor1[+]/Ras64B[+]/Dsor1^S-1221

(Walker et al., 2006)

Nf1^E2 has decreased body size | pupal stage phenotype, non-suppressible by Ras64B^unspecified/phl[+]/Ras64B[+]/Raf¹²

(Walker et al., 2006)

NOT Enhancer of

Statement

Reference

Nf1^E2 is a non-enhancer of increased body size | heat sensitive phenotype of Ilp2^hs.PR

(Walker et al., 2013)

NOT Suppressor of

Statement

Reference

Nf1^E2 is a non-suppressor of increased body size | heat sensitive phenotype of Ilp2^hs.PR

(Walker et al., 2013)

Other

Statement

Reference

Dsor1^KK102276, Nf1^E2, Scer\GAL4^repo has lethal phenotype

(Walker et al., 2013)

Dsor1^KK102276, Nf1^E2, Scer\GAL4^C23 has lethal phenotype

(Walker et al., 2013)

Dsor1^GD9123, Nf1^E2, Scer\GAL4^Ras64B.PW has lethal phenotype

(Walker et al., 2013)

Dsor1^GD9123, Nf1^E2, Scer\GAL4^C23 has lethal phenotype

(Walker et al., 2013)

Dap160^KK102297, Nf1^E2, Scer\GAL4^repo has lethal phenotype

(Walker et al., 2013)

Nf1^E2, Scer\GAL4^Act5C.PU, dnc^KK108541 has lethal - all die during pupal stage phenotype

(Walker et al., 2013)

Mmus\Prkaca^act.2xUAS, Nf1^E2, Scer\GAL4^Act5C.PU has partially lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^act.3xUAS, Nf1^E2, Scer\GAL4^Act5C.PU has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^act.4xUAS, Nf1^E2, Scer\GAL4^Act5C.PU has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^act.4xUAS, Nf1^E2, Scer\GAL4^Feb36 has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^act.4xUAS, Nf1^E2, Scer\GAL4^Ras64B.PW has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^act.4xUAS, Nf1^E2, Scer\GAL4^C23 has lethal - all die during pupal stage phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^Act5C.PU has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^elav.PU has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^Ras64B.PW has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^C23 has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^Feb36 has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^Aug21 has lethal phenotype

(Walker et al., 2013)

Mmus\Prkaca^mC.UAS, Nf1^E2, Scer\GAL4^Akh.PW has partially lethal phenotype

(Walker et al., 2013)

Fak^N30/Fak^KG00304, Nf1[+]/Nf1^E2 has abnormal neuroanatomy | larval stage phenotype

(Tsai et al., 2012)

Alk^UAS.cLa, Nf1^E2, Scer\GAL4^elav-C155 has lethal | recessive | larval stage phenotype

(Gouzi et al., 2011)

Alk^UAS.cLa, Nf1^E2, Scer\GAL4^Ras64B.PW has lethal | recessive | larval stage phenotype

(Gouzi et al., 2011)

Alk^{act.UAS.Tag:HA}, Nf1^E2, Scer\GAL4^elav-C155 has lethal | dominant | larval stage phenotype

(Gouzi et al., 2011)

Alk^UAS.cLa, Nf1^E2, Scer\GAL4^386Y has lethal | recessive | larval stage phenotype

(Gouzi et al., 2011)

Alk^UAS.cLa, Nf1^E2, Scer\GAL4^elav-C155 has lethal | dominant | larval stage phenotype

(Gouzi et al., 2011)

Nf1^E2, Scer\GAL4^elav-C155, jeb^UAS.cVa has lethal | recessive | larval stage phenotype

(Gouzi et al., 2011)

Nf1^E2, Scer\GAL4^Ras64B.PW, jeb^UAS.cVa has lethal | recessive | larval stage phenotype

(Gouzi et al., 2011)

Nf1^E2, Scer\GAL4^386Y, jeb^UAS.cVa has lethal | recessive | larval stage phenotype

(Gouzi et al., 2011)

Alk^{act.UAS.Tag:HA}, Nf1^E2, Scer\GAL4^elav-C155 has lethal | recessive | larval stage phenotype

(Gouzi et al., 2011)

Alk^{act.UAS.Tag:HA}, Nf1^E2, Scer\GAL4^Ras64B.PW has lethal | recessive | larval stage phenotype

(Gouzi et al., 2011)

Alk^{act.UAS.Tag:HA}, Nf1^E2, Scer\GAL4^386Y has lethal | recessive | larval stage phenotype

(Gouzi et al., 2011)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Nf1^E2 has NMJ bouton | increased number | third instar larval stage phenotype, non-enhanceable by spi¹/spi[+]

(Walker et al., 2013)

Suppressed by

Statement

Reference

Nf1^E2 has NMJ bouton | increased number | third instar larval stage phenotype, suppressible by Alk⁹/Alk[+]

(Walker et al., 2013)

Nf1^E2 has NMJ bouton | increased number | third instar larval stage phenotype, suppressible by jeb^weli/jeb[+]

(Walker et al., 2013)

Nf1^E2 has NMJ bouton | increased number | third instar larval stage phenotype, suppressible by cnk[+]/cnk^XE-385

(Walker et al., 2013)

Nf1^E2 has NMJ bouton | increased number | third instar larval stage phenotype, suppressible by Df(1)Exel9051/+

(Walker et al., 2013)

Nf1^E2 has wing phenotype, suppressible | partially by Alk^GD42/Scer\GAL4^Ras64B.PW

(Gouzi et al., 2011)

NOT suppressed by

Statement

Reference

Nf1^E2 has NMJ bouton | increased number | third instar larval stage phenotype, non-suppressible by spi¹/spi[+]

(Walker et al., 2013)

Other

Statement

Reference

Fak^N30/Fak^KG00304, Nf1[+]/Nf1^E2 has NMJ bouton | increased number | larval stage phenotype

(Tsai et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Nf1^E2 has no effect on in the increased pupal length phenotype caused by expression of Ilp2^hs.PR using heat shock.

Expression of jeb^KK111857 under the control of either Scer\GAL4^Ras64B.PW, Scer\GAL4^C23 or Scer\GAL4^nSyb.PS suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of jeb^KK111857 under the control of Scer\GAL4^repo partially suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of Alk^KK102942 under the control of either Scer\GAL4^Ras64B.PW, Scer\GAL4^C23 or Scer\GAL4^nSyb.PS suppresses the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of Scer\GAL4^repo has no significant effect.

Expression of Dsor1^KK102276 under the control of Scer\GAL4^Ras64B.PW at 18[o]C suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of Dsor1^GD9123 under the control of Scer\GAL4^nSyb.PS suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of amx^GD1168 under the control of either Scer\GAL4^Ras64B.PW, Scer\GAL4^C23 or Scer\GAL4^repo at 18[o]C suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of cnk^KK109209 under the control of either Scer\GAL4^Ras64B.PW or Scer\GAL4^C23 suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of CCKLR-17D1^KK108482 under the control of either Scer\GAL4^Ras64B.PW or Scer\GAL4^C23 suppresses the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of Scer\GAL4^repo has no significant effect.

Expression of CCKLR-17D3^GD3431 under the control of either Scer\GAL4^Ras64B.PW, Scer\GAL4^C23 or Scer\GAL4^repo does not suppress the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of Ret^{K805A.Scer\UAS} under the control of Scer\GAL4^Ret.PW does not suppress the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of Dap160^KK102297 under the control of either Scer\GAL4^Ras64B.PW, Scer\GAL4^C23 or Scer\GAL4^nSyb.PS suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of Rab9^KK109041 under the control of either Scer\GAL4^Ras64B.PW or Scer\GAL4^C23 suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of Rab9^{S26N.Scer\UAS.P\T.T:Avic\GFP-YFP} under the control of either Scer\GAL4^Act5C.PU, Scer\GAL4^nSyb.PS or Scer\GAL4^C23 suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

Expression of NAAT1^KK112890 under the control of either Scer\GAL4^Ras64B.PW (in the presence of Dcr-2^Scer\UAS.cDa to enhance RNAi), Scer\GAL4^C23 or Scer\GAL4^nSyb.PS suppresses the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of Scer\GAL4^repo has no significant effect.

Expression of HERC2^KK100181 under the control of Scer\GAL4^Ras64B.PW suppresses the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of either Scer\GAL4^C23 or Scer\GAL4^repo has no significant effect.

Expression of Hs3st-B^KK108793 under the control of either Scer\GAL4^Ras64B.PW or Scer\GAL4^C23 suppresses the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of Scer\GAL4^repo has no significant effect.

The increase in mean number of boutons per neuromuscular junction which is seen in Nf1^E2 third instar larvae is dominantly suppressed by Alk⁹, jeb^weli, cnk^XE-385, and Df(1)Exel9051.

(Walker et al., 2013)

Fak^N30/Fak^KG00304 ; Nf1^E2/+ larvae show an increase in bouton number per muscle area at the neuromuscular junction compared to wild type.

(Tsai et al., 2012)

One copy of Alk¹ partially suppresses the small pupae phenotype seen in Nf1^E2 homozygotes by increasing cell size. The Nf1^E2 olfactory learning phenotype is also partially rescued.

One copy of Alk⁹ partially suppresses the small pupae phenotype seen in Nf1^E2 homozygotes by increasing cell size. The Nf1^E2 olfactory learning phenotype is also partially rescued.

Expression of Alk^Scer\UAS.cLa under the control of Scer\GAL4^elav-C155, Scer\GAL4^Ras64B.PW or Scer\GAL4^386Y in a Nf1^E2 mutant background results in larval lethality. Larval lethality is also seen when Alk^Scer\UAS.cLa is expressed under the control of Scer\GAL4^elav-C155 in a Nf1^E2/+ background.

Expression of jeb^Scer\UAS.cVa under the control of Scer\GAL4^elav-C155, Scer\GAL4^Ras64B.PW or Scer\GAL4^386Y in a Nf1^E2 mutant background results in larval lethality. In a Nf1^E2/+ background pupae are able to develop and the small size phenotype is partially suppressed.

Expression of Alk^{act.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155, Scer\GAL4^Ras64B.PW or Scer\GAL4^386Y in a Nf1^E2 mutant background results in larval lethality. Larval lethality is also seen when Alk^Scer\UAS.cLa is expressed under the control of Scer\GAL4^elav-C155 in a Nf1^E2/+ background.

Expression of Alk^{EC.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^elav-C155 significantly suppresses the small pupae phenotype seen in Nf1^E2 homozygotes. The pupae seen are close to the size of controls. Rescue is also seen when Alk^{EC.Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^Ras64B.PW or Scer\GAL4^386Y but to a lesser extent.

Expression of Alk^GD42 under the control of Scer\GAL4^elav-C155 rescues the small pupae phenotype seen in Nf1^E2 homozygotes. The pupae seen are close to the size of controls. Rescue is also seen when Alk^{EC.Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^Ras64B.PW but the rescue is not as efficient. The increase in size is due to increased cell size rather than increased cell number. Expression of Alk^GD42 under the control of Scer\GAL4^386Y also partially rescues the phenotype in Nf1^E2.

Expression of Alk^{EC.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ey-OK107 does not suppress the small pupae phenotype seen in Nf1^E2 mutants.

Expression of Alk^GD42 under the control of Scer\GAL4^ey-OK107 does not suppress the small pupae phenotype seen in Nf1^E2 mutants.

Expression of Alk^{EC.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Ccap.PP does not suppress the small pupae phenotype seen in Nf1^E2 mutants.

Expression of Alk^GD42 under the control of Scer\GAL4^Ccap.PP does not suppress the small pupae phenotype seen in Nf1^E2 mutants.

Expression of Alk^{EC.Scer\UAS.T:Hsap\MYC} under the control of either the Scer\GAL4^elav-C155, Scer\GAL4^Ras64B.PW or Scer\GAL4^Alk.38 driver, and restricted to the adult stages using Scer\GAL80^ts.αTub84B, rescues the olfactory learning defects seen in Nf1^E2/Nf1^E1 mutants.

Expression of Alk^{EC.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^c747, and restricted to the adult stages using Scer\GAL80^ts.αTub84B, fails to rescue the olfactory learning defects seen in Nf1^E2/Nf1^E1 mutants.

Expression of Alk^GD42 under the control of either the Scer\GAL4^elav-C155, Scer\GAL4^Ras64B.PW or Scer\GAL4^Alk.38 driver, and restricted to the adult stages using Scer\GAL80^ts.αTub84B, rescues the olfactory learning defects seen in Nf1^E2/Nf1^E1 mutants.

Expression of Alk^GD42 under the control of Scer\GAL4^c747, and restricted to the adult stages using Scer\GAL80^ts.αTub84B, fails to rescue the olfactory learning defects seen in Nf1^E2/Nf1^E1 mutants.

(Gouzi et al., 2011)

Xenogenetic Interactions

Statement

Reference

Expression of Mmus\Pkaca^{act.2xScer\UAS} under the control of either Scer\GAL4^Aug21 or Scer\GAL4^Akh.PW suppresses the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of either Scer\GAL4^Feb36, Scer\GAL4^elav.PU, Scer\GAL4^Ras64B.PW or Scer\GAL4^C23 does not significantly suppress the phenotype.

Expression of Mmus\Pkaca^{act.3xScer\UAS} under the control of either Scer\GAL4^Feb36, Scer\GAL4^Aug21 or Scer\GAL4^Akh.PW suppresses the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of either Scer\GAL4^elav.PU, Scer\GAL4^Ras64B.PW or Scer\GAL4^C23 does not significantly suppress the phenotype.

Expression of Mmus\Pkaca^{act.4xScer\UAS} under the control of either Scer\GAL4^Aug21 or Scer\GAL4^Akh.PW suppresses the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of either Scer\GAL4^elav.PU or Scer\GAL4^C23 does not significantly suppress the phenotype.

Expression of Mmus\Pkaca^mC.Scer\UAS under the control of Scer\GAL4^Akh.PW suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

(Walker et al., 2013)

Complementation and Rescue Data

Fails to complement

Nf1^P2

(Walker et al., 2006)

Rescued by

Nf1^E2 is rescued by Scer\GAL4^Act5C.PU/Nf1^UAS.cWa

(Walker et al., 2013)

Nf1^E2 is rescued by Scer\GAL4^elav.PU/Nf1^UAS.cWa

(Walker et al., 2013)

Nf1^E2 is rescued by Nf1^UAS.cWa/Scer\GAL4^Ras64B.PW

(Walker et al., 2013)

Nf1^E2 is rescued by Nf1^UAS.cWa/Scer\GAL4^C23

(Walker et al., 2013)

Nf1^E2 is rescued by Nf1^hs.PT

(Tsai et al., 2012)

Nf1^E2 is rescued by Nf1^hs.PT

(Tsai et al., 2012)

Nf1^E2 is rescued by Nf1^K1481A.hs

(Tsai et al., 2012)

Nf1^E2 is rescued by Nf1^K1481A.hs

(Tsai et al., 2012)

Nf1^E2 is rescued by Scer\GAL4^elav.PU/Nf1^UAS.CFP

(Tsai et al., 2012)

Nf1^E2 is rescued by Scer\GAL4^elav.PU/Nf1^UAS.CFP

(Tsai et al., 2012)

Nf1^E1/Nf1^E2 is rescued by Nf1^UAS.cWa/Scer\GAL4^Alk.38

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 is rescued by Scer\GAL4^elav-C155/Nf1^UAS.cWa/Scer\GAL80^ts.αTub84B

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 is rescued by Nf1^UAS.cWa/Scer\GAL4^Ras64B.PW/Scer\GAL80^ts.αTub84B

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 is rescued by Nf1^UAS.cWa/Scer\GAL4^Alk.38/Scer\GAL80^ts.αTub84B

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 is rescued by Scer\GAL80^Mef2.mb247/Scer\GAL4^elav-C155/Scer\GAL80^Mef2.mb247/Nf1^UAS.cWa

(Gouzi et al., 2011)

Nf1^E2 is rescued by Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI/Nf1^UAS.cWa

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^UAS.cWa/Scer\GAL4^C23

(Walker et al., 2006)

Nf1^E2 is rescued by Scer\GAL4^elav-C155/Nf1^UAS.cWa

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^UAS.cWa/Scer\GAL4^Ras64B.PW

(Walker et al., 2006)

Nf1^E2 is rescued by Scer\GAL4^Ras85D.PW/Nf1^UAS.cWa

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^hs.PT

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^hs.PW

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^{Δ492-1094.hs}

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^{Δ1611-1769.hs}

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^{Δ1770-2265.hs}

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^K1481A.hs

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^{GRD.UAS.Tag:HA}/Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^{GRD.UAS.Tag:HA}/Scer\GAL4^Ras64B.PW

(Walker et al., 2006)

Nf1^E2 is rescued by Nf1^{GRD.UAS.Tag:HA}/Scer\GAL4^Ras85D.PW

(Walker et al., 2006)

Partially rescued by

Nf1^E2 is partially rescued by Nf1^R1320P.hs

(Tsai et al., 2012)

Nf1^E2 is partially rescued by Nf1^R1320P.hs

(Tsai et al., 2012)

Nf1^E2 is partially rescued by Nf1^{Δ1219-1580.hs}

(Tsai et al., 2012)

Nf1^E2 is partially rescued by Nf1^{Δ1219-1580.hs}

(Tsai et al., 2012)

Nf1^E1/Nf1^E2 is partially rescued by Scer\GAL4^elav-C155/Nf1^UAS.cWa

(Walker et al., 2006)

Nf1^E2 is partially rescued by Nf1^{GRD.UAS.Tag:HA}/Scer\GAL4^C23

(Walker et al., 2006)

Nf1^E2 is partially rescued by Nf1^{K1481A.GRD.UAS.Tag:HA}/Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI

(Walker et al., 2006)

Nf1^E2 is partially rescued by Nf1^{K1481A.GRD.UAS.Tag:HA}/Scer\GAL4^C23

(Walker et al., 2006)

Not rescued by

Nf1^E2 is not rescued by Nf1^UAS.cWa/Scer\GAL4^Ret.PW

(Walker et al., 2013)

Nf1^E2 is not rescued by Scer\GAL4^Feb36/Nf1^UAS.cWa

(Walker et al., 2013)

Nf1^E2 is not rescued by Scer\GAL4^Aug21/Nf1^UAS.cWa

(Walker et al., 2013)

Nf1^E2 is not rescued by Scer\GAL4^Akh.PW/Nf1^UAS.cWa

(Walker et al., 2013)

Nf1^E2 is not rescued by Scer\GAL4^C57/Nf1^UAS.CFP

(Tsai et al., 2012)

Nf1^E2 is not rescued by Scer\GAL4^C57/Nf1^UAS.CFP

(Tsai et al., 2012)

Nf1^E2 is not rescued by Scer\GAL4^elav.PU/Nf1^ΔA.UAS.CFP

(Tsai et al., 2012)

Nf1^E2 is not rescued by Scer\GAL4^elav.PU/Nf1^ΔA.UAS.CFP

(Tsai et al., 2012)

Nf1^E1/Nf1^E2 is not rescued by Scer\GAL4^c747/Nf1^UAS.cWa/Scer\GAL80^ts.αTub84B

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 is not rescued by Scer\GAL4^Mef2.247/Nf1^UAS.cWa/Scer\GAL80^ts.αTub84B

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 is not rescued by Scer\GAL4^ey-OK107/Nf1^UAS.cWa/Scer\GAL80^ts.αTub84B

(Gouzi et al., 2011)

Nf1^E1/Nf1^E2 is not rescued by Scer\GAL4^en-e16E/Nf1^UAS.cWa

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^UAS.cWa/Scer\GAL4^repo

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^{Δ1219-1580.hs}

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^R1320A.hs

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^R1320P.hs

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^Q1471R.hs

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^{GRD.UAS.Tag:HA}/Scer\GAL4^repo

(Walker et al., 2006)

Nf1^E2 is not rescued by Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI/Nf1^{R1320A.GRD.UAS.Tag:HA}

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^{R1320A.GRD.UAS.Tag:HA}/Scer\GAL4^C23

(Walker et al., 2006)

Nf1^E2 is not rescued by Scer\GAL4^repo/Nf1^{R1320A.GRD.UAS.Tag:HA}

(Walker et al., 2006)

Nf1^E2 is not rescued by Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI/Nf1^{R1320P.GRD.UAS.Tag:HA}

(Walker et al., 2006)

Nf1^E2 is not rescued by Scer\GAL4^C23/Nf1^{R1320P.GRD.UAS.Tag:HA}

(Walker et al., 2006)

Nf1^E2 is not rescued by Scer\GAL4^repo/Nf1^{R1320P.GRD.UAS.Tag:HA}

(Walker et al., 2006)

Nf1^E2 is not rescued by Scer\GAL4^Ras64B.PW/Nf1^{R1320P.GRD.UAS.Tag:HA}

(Walker et al., 2006)

Nf1^E2 is not rescued by Scer\GAL4^Ras85D.PW/Nf1^{R1320P.GRD.UAS.Tag:HA}

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^{K1468T.GRD.UAS.Tag:HA}/Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^{K1468T.GRD.UAS.Tag:HA}/Scer\GAL4^C23

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^{K1468T.GRD.UAS.Tag:HA}/Scer\GAL4^repo

(Walker et al., 2006)

Nf1^E2 is not rescued by Nf1^{K1481A.GRD.UAS.Tag:HA}/Scer\GAL4^repo

(Walker et al., 2006)

Comments

Expression of Nf1^Scer\UAS.cWa under the control of either Scer\GAL4^Act5C.PU, Scer\GAL4^elav.PU, Scer\GAL4^Ras64B.PW or Scer\GAL4^C23 rescues the reduced pupal length phenotype seen in Nf1^E2 animals, while expression under the control of either Scer\GAL4^Ret.PW, Scer\GAL4^Feb36, Scer\GAL4^Aug21 or Scer\GAL4^Akh.PW does not rescue.

(Walker et al., 2013)

Expression of Nf1^{Scer\UAS.T:Avic\GFP-CFP} under the control of Scer\GAL4^C57 fails to rescue the neuromuscular junction overgrowth phenotype seen in Nf1^E2/Nf1^E2 larvae.

Expression of Nf1^{Scer\UAS.T:Avic\GFP-CFP} under the control of Scer\GAL4^elav.PU rescues the neuromuscular junction overgrowth phenotype seen in Nf1^E2/Nf1^E2 larvae. The increase in EJP amplitude is also largely rescued.

Expression of Nf1^{ΔA.Scer\UAS.T:Avic\GFP-CFP} under the control of Scer\GAL4^elav.PU fails to rescue the neuromuscular junction overgrowth phenotype seen in Nf1^E2/Nf1^E2 larvae.

Nf1^hs.PT rescues the neuromuscular junction overgrowth phenotype seen in Nf1^E2/Nf1^E2 larvae. The reduced body size of Nf1^E2/Nf1^E2 pupae is also rescued.

Nf1^K1481A.hs rescues the neuromuscular junction overgrowth phenotype seen in Nf1^E2/Nf1^E2 larvae. The reduced body size of Nf1^E2/Nf1^E2 pupae is also rescued.

Nf1^R1320P.hs rescues the neuromuscular junction overgrowth phenotype seen in Nf1^E2/Nf1^E2 larvae. The reduced body size of Nf1^E2/Nf1^E2 pupae is not rescued.

Nf1^{Δ1219-1580.hs} rescues the neuromuscular junction overgrowth phenotype seen in Nf1^E2/Nf1^E2 larvae. The reduced body size of Nf1^E2/Nf1^E2 pupae is not rescued.

(Tsai et al., 2012)

Expression of Nf1^Scer\UAS.cWa under the control of Scer\GAL4^Alk.38 rescues the small pupae phenotype seen in Nf1^E2/Nf1^E1 mutants.

Expression of Nf1^Scer\UAS.cWa under the control of the mushroom body drivers Scer\GAL4^c747, Scer\GAL4^Mef2.247 or Scer\GAL4^ey-OK107, and restricted to the adult stages using Scer\GAL80^ts.αTub84B, fails to rescue the olfactory learning defects seen in Nf1^E2/Nf1^E1 mutants.

Expression of Nf1^Scer\UAS.cWa under the control of the mushroom body drivers Scer\GAL4^elav-C155, Scer\GAL4^Ras64B.PW or Scer\GAL4^Alk.38, and restricted to the adult stages using Scer\GAL80^ts.αTub84B, fails to rescue the olfactory learning defects seen in Nf1^E2/Nf1^E1 mutants.

Expression of Nf1[Scer\UAS.cWa] under the control of the pan-neuronal driver Scer\GAL4^elav-C155, as well as Scer\GAL80^Mef2.PT to prevent expression in the mushroom bodies, rescues the olfactory learning defects seen in Nf1^E2/Nf1^E1 animals. Significant rescue is also seen with the Scer\GAL4^Ras64B.PW and Scer\GAL4^Alk.38 drivers.

(Gouzi et al., 2011)

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Wild-type

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Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

NF1^E2

(Moscato et al., 2020, Tsai et al., 2012, Walker et al., 2006)

Nf1^E2

(Gouzi et al., 2011)

dNf1^E2

(Georganta et al., 2021, Walker et al., 2013, Gouzi et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (6)

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