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General Information
Symbol
Dmel\twinGS12209
Species
D. melanogaster
Name
FlyBase ID
FBal0197363
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
twin12209
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    transposable element insertion site
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    The P{GSV6}twinGS12209 insertion maps within a region that overlaps both the twin and cav genes (the insertion is in the twin 5'UTR, in the same orientation as the direction of transcription of twin). The chromosome complements a null allele of cav for both lethality and ovarian phenotypes, indicating that the mutant phenotype is due to an effect on twin and not cav.

    Insertion components
    P{GSV6}twinGS12209
    Product class / Tool use(s)
    Encoded product / tool
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    twinGS8115/twinGS12209 larvae show a significant increase in the number of type 1b boutons at the muscle 6/7 neuromuscular junction compared to controls.

    Embryos derived from twinGS12209/Df(3R)Exel6198 females mated to wild-type males show 66% lethality.

    15% of embryos derived from twinGS12209/Df(3R)crb-F89-4 females that develop a cuticle have head defects, including complete loss of head structures.

    Embryos derived from a cross of homozygous males and females show 94% lethality.

    Embryos derived from twinGS12209/twinGS12209 females mated to wild-type males show 53% lethality.

    Homozygous females show a number of ovarian defects; 60.5% of egg chambers are wild-type, but 4% have less than 15 nurse cells, 17.5% have more than 15 nurse cells, 14% show degeneration and 4% have other defects.

    twinGS12209/Df(3R)crb-F89-4 females show a number of ovarian defects; 37% of egg chambers are wild-type, but 7.5% have less than 15 nurse cells, 32% have more than 15 nurse cells, 17.5% show degeneration and 6% have other defects. Eggs chambers containing oocytes with five ring canals are seen, indicating that the cyst has undergone an extra round of division.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    twinGS12209/+ ; Patr-1d3/+ double heterozygous larvae show a significant increase in the number of type 1b boutons at the muscle 6/7 neuromuscular junction compared to controls.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (3)