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General Information
Symbol
Dmel\twinGS8115
Species
D. melanogaster
Name
FlyBase ID
FBal0197364
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
twin8115
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Insertion in intron 5. The orientation of the insertion is the same as the direction of transcription of twin.

    Insertion components
    P{GSV3}twinGS8115
    Product class / Tool use(s)
    Encoded product / tool
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    100% of germaria lack germline stem cells (GSCs) in the ovaries of 7 day old twinGS8115/Df(3R)Exel6198 females.

    Homozygous clonal GSCs are lost more rapidly from the germaria than control germline clones. Division in the mutant GSCs s slower than in wild type.

    twinGS8115/twinGS12209 larvae show a significant increase in the number of type 1b boutons at the muscle 6/7 neuromuscular junction compared to controls.

    Embryos derived from twinGS8115/twinGS8115 females mated to wild-type males show 78% lethality.

    No eggs are produced from a cross of twinGS8115/Df(3R)Exel6198 females mated to wild-type males.

    Homozygous females show a number of ovarian defects; 6% of egg chambers are wild-type, but 34% have less than 15 nurse cells, 36% have more than 15 nurse cells and 24% show degeneration.

    twinGS8115/Df(3R)crb-F89-4 females show a number of ovarian defects; 14% of egg chambers are wild-type, but 20% have less than 15 nurse cells, 20% have more than 15 nurse cells, 43.5% show degeneration and 2.5% have other defects.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    twinGS8115/+ ; Patr-1d3/+ double heterozygous larvae show a significant increase in the number of type 1b boutons at the muscle 6/7 neuromuscular junction compared to controls.

    Embryos derived from twinGS8115 smg1 double heterozygotes show 32% lethality, whereas embryos derived from either single mutant do not show maternal effect lethality.

    Over 40% of eggs laid by twinGS8115/+, Pabp255/+ females fail to hatch.

    Xenogenetic Interactions
    Statement
    Reference

    twinGS8115 suppresses the wing posture defects seen upon expression of Hsap\PABPN117ala.Act88F.

    twinGS8115 suppresses the wing posture defects seen when Hsap\PABPN117ala.Scer\UAS is expressed under the control of Scer\GAL4Mhc.PW. The number of nuclei containing aggregates increases in the presence of twinGS8115, although the cross-sectional area remains the same.

    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (5)