FlyBase Allele Report: Dmel\Upf1[UASp.GFP]

General Information

Symbol

Dmel\Upf1^UASp.GFP

Species

D. melanogaster

Name

FlyBase ID

FBal0197468

Feature type

allele

Associated gene

Dmel\Upf1

Associated Insertion(s)

Carried in Construct

P{UASp-GFP.Upf1}

Key Links

Transgenic product class

wild_type

(Saxton, 2007.7)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Saxton, 2007.7)

Mutagen

in vitro construct

(Saxton, 2007.7)

Progenitor genotype

Carried in construct

P{UASp-GFP.Upf1}

Cytology

Description

UASp regulatory sequences drive expression of the wild-type Upf1 coding sequence which is tagged at the N-terminal end with GFP.

(Saxton, 2007.7)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Upf1

Tagged with

GFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Zuniga et al., 2023)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-PR^PO-36.UAS

(Xu et al., 2019)

modeled by Zzzz\poly-GR^36.UAS.EGFP

(Xu et al., 2019)

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Zaepfel et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Toll-6-D42/Upf1^UASp.GFP is a suppressor of short lived phenotype of Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP

(Xu et al., 2019)

Scer\GAL4^Toll-6-D42/Upf1^UASp.GFP is a suppressor | partially of decreased cell number | adult stage phenotype of Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP

(Xu et al., 2019)

Scer\GAL4^Toll-6-D42/Upf1^UASp.GFP is a suppressor of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP

(Xu et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^Toll-6-D42/Upf1^UASp.GFP is a suppressor | partially of adult antennal lobe phenotype of Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP

(Xu et al., 2019)

Scer\GAL4^Toll-6-D42/Upf1^UASp.GFP is a suppressor | partially of adult motor neuron phenotype of Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP

(Xu et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

24623

w^*; P{UASp-GFP.Upf1}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Upf1<up>OE

(Zuniga et al., 2024)

Upf1^{Scer\UAS.P\T.T:Avic\GFP}

Upf1^{Scer\UAS.T:Avic\GFP}

Upf1^UASp.GFP

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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