FB2025_05 , released December 11, 2025
Allele: Dmel\eys734
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General Information
Symbol
Dmel\eys734
Species
D. melanogaster
Name
FlyBase ID
FBal0197482
Feature type
allele
Associated gene
Dmel\eys
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Husain et al., 2006)
Mutagen
ethyl methanesulfonate
(Husain et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: E521K.

(Husain et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:2,339,532..2,339,532 [+]
Nucleotide change:

G2339532A

Amino acid change:

E521K | eys-PE; E521K | eys-PF

Reported amino acid change:

E521K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Husain et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous ommatidia completely lack the inter-rhabdomeral space.

      (Haltom et al., 2014)

      Mutant files do not show normal entrainment to temperature cycles in assays studying locomotor rhythms.

      (Sehadova et al., 2009)

      eys734 mutants do not display optical isolation of photoreceptor cells. Ultra-structural analysis shows that rhabdomeres and stalk membranes are in close contact in eys734 mutants and individual rhabdomeres are often fragmented.

      eys734/Df(2L)BSC37 mutants exhibit the same axonal projections between the eye and the brain as in wild-type. In addition, these mutants do not show defects in external eye morphology or retinal cell-type specification and patterning.

      eys734 mutants do not exhibit defects in chordotonal organ organisation or sensory dendrite morphology. In addition, behavioural tests for touch sensitivity do not reveal any defects in mechanoreceptor function.

      (Husain et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      eys734/eys[+] is an enhancer of rhabdomere phenotype of rumiΔ26

      (Haltom et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      eys734/+ strongly enhances the rhabdomere attachment phenotype of rumiΔ26 homozygotes raised at 18[o]C: multiple rhabdomeres collapse into one another in each ommatidium and there is a dramatic decrease in the size of the inter-rhabdomeral space (although small pockets of it are still present in each ommatidium).

      (Haltom et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      eys734
      (Haltom et al., 2014, Sehadova et al., 2009, Husain et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)