FlyBase Allele Report: Dmel\SoxN[K439.UAS]

General Information

Symbol

Dmel\SoxN^K439.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0197573

Feature type

allele

Associated gene

Dmel\SoxN

Associated Insertion(s)

Carried in Construct

P{UAS-SoxN.K439R}

Key Links

Transgenic product class

missense_variant

(Savare et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Savare et al., 2005)

Mutagen

in vitro construct

(Savare et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-SoxN.K439R}

Cytology

Description

Amino acid replacement: K439R.

(Savare et al., 2005)

UAS regulatory sequences drive expression of SoxN, that has a K439R substitution which stops the expressed product from being modified with a SUMO group.

(Savare et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

SoxN

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult head, with Scer\GAL4^ey.PB

(Savare et al., 2005)

axon & ventral nerve cord, with Scer\GAL4^elav.PLu

(Girard et al., 2006)

larval anterior commissure, with Scer\GAL4^da.G32

(Savare et al., 2005)

larval anterior commissure, with Scer\GAL4^elav.PLu

(Girard et al., 2006)

larval longitudinal connective, with Scer\GAL4^da.G32

(Savare et al., 2005)

larval longitudinal connective, with Scer\GAL4^elav.PLu

(Girard et al., 2006)

larval posterior commissure, with Scer\GAL4^da.G32

(Savare et al., 2005)

larval posterior commissure, with Scer\GAL4^elav.PLu

(Girard et al., 2006)

Detailed Description

Statement

Reference

Expression of SoxN^{K439.Scer\UAS} under the control of Scer\GAL4^elav.PLu in embryos results in specific defects in the axon scaffolding in the ventral nerve cord, including fusing and widening of the anterior and posterior commissures, thickening of the longitudinal connectives, and tangles at the segmental boundaries.

(Girard et al., 2006)

Expression of SoxN^{K439.Scer\UAS} in the eye disc, driven by Scer\GAL4^ey.PB, results in a few adult escapers with a headless phenotype.

Expression of SoxN^{K439.Scer\UAS} in the embryo, under the control of Scer\GAL4^da.G32, results in defects in the central nervous system followed by lethality at the end of embryogenesis. CNS defects include the fusion or absence of commissures and the reduction or absence of longitudinal axon tracts.

(Savare et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

SoxN^{K439.Scer\UAS}

SoxN^K439.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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