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General Information
Symbol
Dmel\spoZ339
Species
D. melanogaster
Name
FlyBase ID
FBal0197742
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
A5591825T
Amino acid change:
K132term | spo-PA; K132term | spo-PC
Reported amino acid change:
K132term
Comment:
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: K132term.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
spoZ339 embryos show normal development until stage 14. After this stage, spoZ339 embryos exhibit head involution failure, an absence of midgut and dorsal closure, an abnormal hindgut looping and a lack of cuticle differentiation. These defects are seen at the same level in embryos from spoZ339 germline clones and zygotic mutants, indicating that there is no spoZ339 maternal contribution. spoZ339/spoZ303 embryos rarely hatch. When an artificial pulse of 20E is delivered to these embryos midway through embryogenesis, approximately 30% survive to hatch and 20% survive to adulthood. Rescued spoZ339/spoZ303 females produce no progeny due to arrest of egg development at stage 8 of oogenesis, while rescued males are fertile. An artificial pulse of E allows 25% of spoZ339/spoZ303 embryos to hatch and 12% to become adults. A pulse of ketotriol allows 13% to hatch but only 1% survive to become adults. In contrast, pulses of ketodiol and 7dC do not rescue the lethality of spoZ339/spoZ303 embryos at all.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
DmspoZ339
spoZ339
Name Synonyms
Secondary FlyBase IDs
    References (1)