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General Information
Symbol
Dmel\spri6G1
Species
D. melanogaster
Name
FlyBase ID
FBal0197824
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{EP}EP1492 has deleted sequence encoding exons 1-6 of the spri b-isoform (exon 1 starts just 5' of the P{EP}EP1492 insertion site).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

spri6G1 homozygous adults are resistant to acute food deprivation, as compared to controls. Larval fat body cells show decreased density of Rab5-positive vesicular structures in fed individuals, but not in starved individuals, as compared to controls.

spri6G1 mutants do not exhibit any discernible phenotype in the adult brain.

spri6G1 homozygous flies are viable and fertile with normal oogenesis.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

spri6G1/spri6G1 is a suppressor of short lived | calorie restriction conditional phenotype of vap2

spri6G1/spri[+] is a suppressor of short lived | calorie restriction conditional phenotype of vap2

spri6G1/spri[+] is a suppressor of abnormal neuroanatomy phenotype of vap2

Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

spri6G1 is a suppressor of adult brain phenotype of vap2

Other
Additional Comments
Genetic Interactions
Statement
Reference

vap2/vap2, spri6G1/spri6G1 and vap2/+, spri6G1/spri6G1 double mutants show the same increased resistance to acute food deprivation to spri6G1/spri6G1 single mutants, instead of the hypersensitivity observed in vap2/vap2 single mutants.

A homozygous spri6G1 mutant background significantly suppresses the vap2 neurodegenerative phenotype. Weaker suppression is seen in a spri6G1 heterozygous background.

Migration of border follicle cells is normal in spri6G1 homozygotes, or in flies carrying EgfrScer\UAS.cBa or PvrScer\UAS.cDa with Scer\GAL4slbo.2.6, but significant defects in border cell migration, including some instances of complete failure of migration are seen in spri6G1/spri6G1 EgfrScer\UAS.cBa; Scer\GAL4slbo.2.6 flies. Weaker border cell migration defects are seen in spri6G1/spri6G1 PvrScer\UAS.cDa Scer\GAL4slbo.2.6 flies.

spri6G1/spri6G1 also enhances the migration defects seen in border follicle cells in CblF165 homozygous somatic clones. I these animals, border follicle cell clusters rarely reach the oocyte.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)