|Feature type||allele||Associated gene||Dmel\aur|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
neuroblast | supernumerary & larva
neuroblast | supernumerary & larval brain
spindle & neuroblast & larva
spindle & sensory mother cell & pupa
Mutants show a massive increase in larval brain neuroblasts, developing more than 1000 central brain neuroblasts at stages where wild-type larvae have only 95-100 neuroblasts. The mutant neuroblasts are proliferative and can generate neuronal progeny. The orientation of the mitotic spindle is essentially randomised relative to the apical/basal cortical polarity axis in mutant metaphase neuroblasts, in contrast to wild-type metaphase neuroblasts where the mitotic spindle is aligned within 150 of the center of the apical/basal cortical polarity axis. Single cell mutant clones induced in a single neuroblast typically generate a clone containing multiple neuroblasts as well as a pool of smaller ganglion mother cell(GMC)/neuronal progeny, in contrast to single cell wild-type clones which give rise to one large neuroblast and a population of smaller GMC/neuronal progeny. Mutant pupal sensory organ precursor (SOP) cells show nearly random spindle orientation relative to the cortical polarity axis, in contrast to wild-type SOP cells. Mutant neuroblasts in explanted larval brains show both asymmetric and symmetric (17%) cell divisions, in contrast to wild-type controls which always divide asymmetrically.
Homozygous larvae have supernumerary neuroblasts.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 4 )|
|Secondary FlyBase IDs|
|References ( 2 )|