Allele Dmel\aur¹⁴⁶⁴¹

General Information
Symbol	Dmel\aur¹⁴⁶⁴¹	Species	D. melanogaster
Name		FlyBase ID	FBal0197864
Feature type	allele	Associated gene	Dmel\aur

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Wang et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: V302E. (Wang et al., 2006, Lee et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pupal stage (Lee et al., 2006) lethal \| pupal stage \| recessive (Wang et al., 2006) neuroanatomy defective (Wang et al., 2006, Lee et al., 2006) neuroanatomy defective \| somatic clone (Lee et al., 2006)
Phenotype Manifest In
	neuroblast \| somatic clone \| supernumerary (Lee et al., 2006) neuroblast \| supernumerary & larva (Wang et al., 2006) neuroblast \| supernumerary & larval brain (Lee et al., 2006) spindle & neuroblast & larva (Lee et al., 2006) spindle & sensory mother cell & pupa (Lee et al., 2006)
Detailed Description
	Statement Reference Mutants show a massive increase in larval brain neuroblasts, developing more than 1000 central brain neuroblasts at stages where wild-type larvae have only 95-100 neuroblasts. The mutant neuroblasts are proliferative and can generate neuronal progeny. The orientation of the mitotic spindle is essentially randomised relative to the apical/basal cortical polarity axis in mutant metaphase neuroblasts, in contrast to wild-type metaphase neuroblasts where the mitotic spindle is aligned within 15⁰ of the center of the apical/basal cortical polarity axis. Single cell mutant clones induced in a single neuroblast typically generate a clone containing multiple neuroblasts as well as a pool of smaller ganglion mother cell(GMC)/neuronal progeny, in contrast to single cell wild-type clones which give rise to one large neuroblast and a population of smaller GMC/neuronal progeny. Mutant pupal sensory organ precursor (SOP) cells show nearly random spindle orientation relative to the cortical polarity axis, in contrast to wild-type SOP cells. Mutant neuroblasts in explanted larval brains show both asymmetric and symmetric (17%) cell divisions, in contrast to wild-type controls which always divide asymmetrically. (Lee et al., 2006) Homozygous larvae have supernumerary neuroblasts. (Wang et al., 2006)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference aur¹⁴⁶⁴¹ has neuroanatomy defective phenotype, suppressible \| partially by Scer\GAL4^wor.PA/numb^Scer\UAS.cWa (Lee et al., 2006)
Phenotype Manifest In
Suppressed by
Statement Reference aur¹⁴⁶⁴¹ has neuroblast \| supernumerary & larval brain phenotype, suppressible \| partially by Scer\GAL4^wor.PA/numb^Scer\UAS.cWa (Lee et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	aur¹⁴⁶⁴¹ (Wang et al., 2006) aurA¹⁴⁶⁴¹ (Lee et al., 2006) l(3)LL14641 (Wang et al., 2006) l(3)LL-14641 (Lee et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Lee et al., 2006, Genes Dev. 20(24): 3464--3474 Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. [FBrf0195248] Wang et al., 2006, Genes Dev. 20(24): 3453--3463 Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. [FBrf0194325]

Allele Dmel\aur14641

Allele Dmel\aur¹⁴⁶⁴¹