FB2025_02 , released April 17, 2025
Allele: Hsap\SERPINI1UAS.cKa
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General Information
Symbol
Hsap\SERPINI1UAS.cKa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Kinghorn
FlyBase ID
FBal0197910
Feature type
allele
Associated gene
Hsap\SERPINI1
Associated Insertion(s)
Carried in Construct
P{UAS-NS.K}
Key Links
Transgenic product class
wild_type
(Kinghorn et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kinghorn et al., 2006)
Mutagen
in vitro construct
(Kinghorn et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-NS.K}
Cytology
Description

UASt regulatory sequences drive expression of wild-type Hsap\SERPINI1 (containing its secretion signal peptide).

(Kinghorn et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\SERPINI1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\SERPINI1Scer\UAS.cKa under the control of Scer\GAL4GMR.PF at 29oC results in a rough eye phenotype with reduction in the number of ommatidia and malformation of the cornea. The most strongly affected eyes have necrotic intrusions.

      Some animals can hatch when they are expressing Hsap\SERPINI1Scer\UAS.cKa under the control of Scer\GAL4hs.2sev at 25oC.

      Co-expression of Hsap\SERPINI1RLP.Scer\UAS suppresses the lethality caused by expression of Hsap\SERPINI1Scer\UAS.cKa under the control of Scer\GAL4unspecified.

      (Kinghorn et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\SERPINI1Scer\UAS.cKa
      Hsap\SERPINI1UAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Kinghorn
      Secondary FlyBase IDs
        References (3)