|Feature type||allele||Associated gene||Dmel\Tip60|
|Mutagen||in vitro construct - regulatory fusion, in vitro construct - RNAi|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
Pre-synaptic expression of Tip60[dsRNA.Z.Scer\UAS] under the control of Scer\GAL4[elav-C155] results in pupal lethality.There is a significant increase in the total number of synaptic boutons in Tip60[E431Q.Scer\UAS]-expressing larvae, when compared to wild-type controls. There is a substantially larger expansion of type-I boutons compared to type-Ib in these mutants. There is also a slight increase in the number of satellite boutons in these mutants compared to controls. This increase in bouton number is accompanied by an excess of futsch-associated microtubule looping and splaying. Post-synaptic expression of Tip60[dsRNA.Z.Scer\UAS] under the control of Scer\GAL4[Mef2.247] results in pupal lethality. Mutant larvae exhibit a significant reduction in bouton number, specifically in 1s boutons, as well as the absence of satellite boutons.
Expression of Tip60dsRNA.Z.Scer\UAS under the control of Scer\GAL4how-24B results in a reduction in viability. The flies die at a broad range of developmental stages, depending on the insertion line used, beginning from early pupae to directly before eclosion. The apparent cause of lethality later in development appears to be due to an inability to eclose from the pupal casing.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 2 )|