Allele Dmel\Tip60^{dsRNA.Z.Act5C}

General Information
Symbol	Dmel\Tip60^{dsRNA.Z.Act5C}	Species	D. melanogaster
Name		FlyBase ID	FBal0198014
Feature type	allele	Associated gene	Dmel\Tip60

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - RNAi
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Zhu et al., 2007) in vitro construct - RNAi (Zhu et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference An Act5C promoter drives expression of an inverted repeat of 613bp of Tip60 sequence (nucleotides 871-1483) in sense-antisense orientation. The repeat sequences are separated by an ATCTA polylinker. (Zhu et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	cell lethal (Zhu et al., 2007) cytokinesis defective (Zhu et al., 2007)
Phenotype Manifest In

Detailed Description
	Statement Reference D.Mel-2 cells transfected with Tip60^{dsRNA.Z.Act5C} grow poorly, suffering approximately 50-70% lethality 24 hours post-transfection. Those cells that do survive are larger than control cells and appear to be arrested during cytokinesis. (Zhu et al., 2007)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Carried in plasmid "Dmel\TIP60/RNAi/pAc5.1", transfected into D.Mel-2 cells and used to study the phenotypic consequences of dsRNA interference (RNAi) of the Tip60 gene. (Zhu et al., 2007)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Tip60^{dsRNA.Z.Act5C}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Zhu et al., 2007, Genetics 175(3): 1229--1240 The cloning and characterization of the histone acetyltransferase human homolog Dmel\TIP60 in Drosophila melanogaster: Dmel\TIP60 is essential for multicellular development. [FBrf0200176]

Allele Dmel\Tip60dsRNA.Z.Act5C

Allele Dmel\Tip60^{dsRNA.Z.Act5C}