FB2025_01 , released February 20, 2025
Allele: Dmel\swmF15
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General Information
Symbol
Dmel\swmF15
Species
D. melanogaster
Name
FlyBase ID
FBal0198060
Feature type
allele
Associated gene
Dmel\swm
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Casso et al., 2008, Casso, 2007.10.15)
Mutagen
diepoxybutane
(Casso et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: D923N.

(Casso et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,496,795..19,496,795 [+]
Nucleotide change:

G19496795A

Amino acid change:

D921N | swm-PA; D921N | swm-PB; D922N | swm-PC; D922N | swm-PD

Reported amino acid change:

D923N

Comment:

The mapped position of the mutation is correct based on the sequence shown in Figure 3, depite the fact that the mapped amino acid coordinate does not match the coordinate reported in the text.

(Casso et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      swmF15/Df(2L)Exel8041 adult escapers have an increased distance between veins 3 and 4 in the wing and misoriented wing hairs.

      swmF15/swm37Dh-1 adult escapers have an increased distance between veins 3 and 4 in the wing compared to controls and 76% of the wings have patches of wing hairs that show abnormal orientation.

      76% of the wings of swmF15/swmF14 adult escapers have patches of wing hairs that show abnormal orientation.

      Homozygous clones induced in the wing disc are small (up to 8 cells) and few in number.

      Females carrying homozygous germline clones generate fertile eggs and heterozygous adults derived from these eggs are phenotypically normal, while swm37Dh-1/swmF15 progeny of swmF15 female germline clones are larval lethal.

      (Casso et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      swmF15/swm[+] is a non-suppressor of visible phenotype of Scer\GAL4ptc-559.1, smoRNAi.UAS.WIZ

      (Casso et al., 2008)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      swmF15/swm[+] is a non-suppressor of wing vein phenotype of Scer\GAL4ptc-559.1, smoRNAi.UAS.WIZ

      (Casso et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      swm37Dh-1

      (Casso et al., 2008)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      swmF15
      (Yamamoto-Hino et al., 2010, Casso et al., 2008, Casso, 2007.10.15)
      swm[F15]
      (Yamamoto-Hino et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)