FlyBase Allele Report: Dmel\Nmnat[Δ4790-1]

General Information

Symbol

Dmel\Nmnat^Δ4790-1

Species

D. melanogaster

Name

FlyBase ID

FBal0198134

Feature type

allele

Associated gene

Dmel\Nmnat

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Zhai et al., 2006)

Mutagen

P-element activity

(Zhai et al., 2006)

Progenitor genotype

P{EPgy2}EY04790

(Zhai et al., 2006)

Cytology

Description

Imprecise excision of the P{EPgy2} element, resulting in deletion of the first four exons of the Nmnat gene.

(Zhai et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | somatic clone

(Neukomm et al., 2017)

abnormal neurophysiology | somatic clone

(Zhai et al., 2006)

lethal

(Ruan et al., 2015)

lethal - all die before end of first instar larval stage

(Zhai et al., 2006)

some die during first instar larval stage

(Zhai et al., 2006)

Phenotype Manifest In

axon | adult stage | somatic clone

(Neukomm et al., 2017)

neuronal cell body | adult stage | somatic clone

(Neukomm et al., 2017)

optic cartridge | somatic clone

(Zhai et al., 2006)

sensory neuron | adult stage | somatic clone

(Neukomm et al., 2017)

Detailed Description

Statement

Reference

Nmnat^Δ4790-1 mutant clones in sensory neurons in the adult wing undergo rapid degeneration affecting cell bodies as well as axons.

(Neukomm et al., 2017)

Flies with eyes that contain Nmnat^Δ4790-1 clones show reduced depolarization and on/off responses in electroretinogram (ERG) recordings and show photoreceptor synaptic defects.

(Zhai et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Nmnat^Δ4790-1 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by axed⁰⁰¹¹

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴/Sarm⁸⁹⁶

(Neukomm et al., 2017)

NOT suppressed by

Statement

Reference

Nmnat^Δ4790-1 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Sarm⁸⁹⁶

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Sarm⁴⁶²¹

(Neukomm et al., 2017)

Nmnat^Δ4790-1, axed⁰⁰¹¹ has abnormal wound healing | adult stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Sarm^{ΔARM.UAS.Tag:MYC}

(Neukomm et al., 2017)

Nmnat^Δ4790-1, axed²⁰⁹⁴ has abnormal wound healing | adult stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Sarm^{ΔARM.UAS.Tag:MYC}

(Neukomm et al., 2017)

Other

Statement

Reference

Nmnat^Δ4790-1, axed⁰⁰¹¹ has abnormal stress response | somatic clone | adult stage phenotype

(Hsu et al., 2021)

Nmnat^Δ4790-1, axed⁰⁰¹¹ has abnormal wound healing | adult stage phenotype

(Neukomm et al., 2017)

Nmnat^Δ4790-1, axed²⁰⁹⁴ has abnormal wound healing | adult stage phenotype

(Neukomm et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Nmnat^Δ4790-1 has sensory neuron | somatic clone | adult stage phenotype, suppressible by axed⁰⁰¹¹

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has axon | somatic clone | adult stage phenotype, suppressible by axed⁰⁰¹¹

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has neuronal cell body | somatic clone | adult stage phenotype, suppressible by axed⁰⁰¹¹

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has sensory neuron | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has axon | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has neuronal cell body | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has sensory neuron | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴/Sarm⁸⁹⁶

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has axon | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴/Sarm⁸⁹⁶

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has neuronal cell body | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴/Sarm⁸⁹⁶

(Neukomm et al., 2017)

NOT suppressed by

Statement

Reference

Nmnat^Δ4790-1 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Sarm⁸⁹⁶

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has axon | somatic clone | adult stage phenotype, non-suppressible by Sarm⁸⁹⁶

(Neukomm et al., 2017)

Nmnat^Δ4790-1, axed²⁰⁹⁴ has axon | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Sarm^{ΔARM.UAS.Tag:MYC}

(Neukomm et al., 2017)

Nmnat^Δ4790-1, axed²⁰⁹⁴ has neuronal cell body | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Sarm^{ΔARM.UAS.Tag:MYC}

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has neuronal cell body | somatic clone | adult stage phenotype, non-suppressible by Sarm⁸⁹⁶

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Sarm⁴⁶²¹

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has axon | somatic clone | adult stage phenotype, non-suppressible by Sarm⁴⁶²¹

(Neukomm et al., 2017)

Nmnat^Δ4790-1 has neuronal cell body | somatic clone | adult stage phenotype, non-suppressible by Sarm⁴⁶²¹

(Neukomm et al., 2017)

Nmnat^Δ4790-1, axed⁰⁰¹¹ has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Sarm^{ΔARM.UAS.Tag:MYC}

(Neukomm et al., 2017)

Nmnat^Δ4790-1, axed⁰⁰¹¹ has axon | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Sarm^{ΔARM.UAS.Tag:MYC}

(Neukomm et al., 2017)

Nmnat^Δ4790-1, axed⁰⁰¹¹ has neuronal cell body | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Sarm^{ΔARM.UAS.Tag:MYC}

(Neukomm et al., 2017)

Nmnat^Δ4790-1, axed²⁰⁹⁴ has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Sarm^{ΔARM.UAS.Tag:MYC}

(Neukomm et al., 2017)

Other

Statement

Reference

Nmnat^Δ4790-1, axed⁰⁰¹¹ has axon | somatic clone | adult stage phenotype

(Hsu et al., 2021)

Nmnat^Δ4790-1, axed⁰⁰¹¹ has wing nerve | somatic clone phenotype

(Hsu et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The axon and cell body degeneration in Nmnat^Δ4790-1 sensory neuron clones in the adult wing can be fully rescued by combination with axed⁰⁰¹¹, axed²⁰⁹⁴ or by axed²⁰⁹⁴ and Ect4⁸⁹⁶ together, but not by combination with either Ect4⁸⁹⁶ or Ect4⁴⁶²¹ alone.

The Nmnat^Δ4790-1,axed⁰⁰¹¹ as well as Nmnat^Δ4790-1,axed²⁰⁹⁴ double mutant clones display defective injury-induced axon degeneration (severed axons remain intact following an axotomy, instead of being cleared away) which cannot be overcome by expressing Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} under the Scer\GAL4^VGlut-OK371 driver in the mutant clones.

(Neukomm et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Nmnat²

(Zhai et al., 2006)

Nmnat¹

(Zhai et al., 2006)

Rescued by

Nmnat^Δ4790-1 is rescued by Scer\GAL4^Act.PU/Nmnat^UAS.PA