Allele Dmel\Mnn1^Δ46

General Information
Symbol	Dmel\Mnn1^Δ46	Species	D. melanogaster
Name		FlyBase ID	FBal0198138
Feature type	allele	Associated gene	Dmel\Mnn1

Allele class	amorphic allele - genetic evidence
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Cerrato et al., 2006)
Mutagen	Delta2-3 (Cerrato et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{wHy}Mnn1^DG30701 (Cerrato et al., 2006)
Nature of the lesion	Statement Reference Imprecise excision of the P{wHy} element resulting in the deletion of 186bp of the Mnn1 gene, including 70bp downstream of the first ATG and complete removal of the P{wHy} insertion. (Cerrato et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	fertile (Cerrato et al., 2006) fertile (with Df(2L)J-H) (Cerrato et al., 2006) fertile (with Df(2L)Mnn1^Δ65) (Cerrato et al., 2006) short lived \| male (Cerrato et al., 2006) short lived \| male (with Mnn1^Δ79) (Cerrato et al., 2006) viable (Cerrato et al., 2006) viable (with Df(2L)J-H) (Cerrato et al., 2006) viable (with Df(2L)Mnn1^Δ65) (Cerrato et al., 2006)
Phenotype Manifest In

Detailed Description
	Statement Reference Mnn1^Δ46 and Mnn1^Δ46/Mnn1^Δ79 males show a constant rate of early mortality in days 1-30. These flies also appear to be slightly more resistant to the herbicide paraquat, although this is in contrast to previous reports of other Mnn1 mutants showing increased sensitivity to paraquat. (Cerrato et al., 2006)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference Mnn1^Δ46/Mnn1^Δ79, Scer\GAL4^how-24B/Scer\GAL4^how-24B, kay^{bZip.Scer\UAS} has lethal \| prepupal stage phenotype (Cerrato et al., 2006)
Phenotype Manifest In
Other
Statement Reference Mnn1[+]/Mnn1^Δ46, Scer\GAL4^how-24B/Scer\GAL4^how-24B, kay^{bZip.Scer\UAS} has adult thorax phenotype (Cerrato et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference Expression of kay^{bZip.Scer\UAS} under the control of Scer\GAL4^how-24B in a Mnn1^Δ46/+ background results in a moderate thoracic cleft phenotype, while no phenotype is observed in a wild-type background. Scer\GAL4^how-24B>kay^{bZip.Scer\UAS} expression in a Mnn1^Δ46/Mnn1^Δ79 background results in pre-pupal lethality. (Cerrato et al., 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Mnn1^Δ46 mnn1^Δ46 (Cerrato et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Cerrato et al., 2006, Dev. Biol. 298(1): 59--70 Genetic interactions between Drosophila melanogaster menin and Jun/Fos. [FBrf0192703]

Allele Dmel\Mnn1Δ46

Allele Dmel\Mnn1^Δ46