wing margin bristle | ectopic & anterior wing margin
sensE2/+ results in an approximately 35% reduction in the loss of wing margin caused by mir-9aJ22/mir-9aE39. sensE2/+ does not rescue the increased cell death seen in the wing discs of mir-9aJ22/mir-9aE39 animals.
BxhdpR26/+ fully rescues the adult wing margin defects of mir-9aJ22 homozygotes and mir-9aJ22/mir-9aE39 animals. BxhdpR26/+ strongly suppresses the ectopic apoptosis seen in the wing discs of mir-9aJ22/mir-9aE39 animals.
The presence of BxhdpR26/+ partially suppresses the formation of ectopic anterior postalar bristles seen in mir-9aJ22/mir-9aE39 adults, but has only mild effects on the formation of ectopic dorsocentral bristles seen in these flies.
One copy of sensE58 substantially rescues the wing margin defects of mir-9aJ22 homozygotes; about 30% of the double mutant flies have wings that are indistinguishable from wild type, while others lack only a small part of the posterior margin. The bristles on the anterior wing margin resemble wild type in the double mutant flies.
Expression of mir-9aScer\UAS.cLa under the control of Scer\GAL4ap-md544 completely rescues the continuity of the wing margin in mir-9aJ22/mir-9aE39 animals. In the developing wing disc, the increased apoptosis seen in the wing pouch in mir-9aJ22/mir-9aE39 animals is rescued in the dorsal compartment by expression of mir-9aScer\UAS.cLa under the control of Scer\GAL4ap-md544.