FB2025_01 , released February 20, 2025
Allele: Dmel\LanB2MB04039
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General Information
Symbol
Dmel\LanB2MB04039
Species
D. melanogaster
Name
FlyBase ID
FBal0198406
Feature type
allele
Associated gene
Dmel\LanB2
Associated Insertion(s)
Mi{ET1}LanB2MB04039
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Wolfstetter and Holz, 2012)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}LanB2MB04039
    Cytology
    Description

    Insertion in the 3' UTR.

    (Wolfstetter and Holz, 2012)
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In embryos mutant for LanB2MB04039, proximal gland cells do not complete their posterior turn, resulting in folded glands. Quantification of the salivary gland migration defect shows that approximately 79% of LanB2MB04039 mutant glands fail to complete their posterior migration.

        LanB2MB04039 mutant embryos display salivary gland invagination defects where proximal gland cells remain at the ventral surface of the embryo. Salivary glands of LanB2MB04039 mutant embryos that fail to invaginate do not have branched lumens.

        (Patel and Myat, 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        LanB2MB04039 has abnormal cell migration phenotype, enhanceable by Gyc76C2388

        (Patel and Myat, 2013)
        Enhancer of
        Statement
        Reference

        LanB2MB04039 is an enhancer of abnormal cell migration phenotype of Gyc76C2388

        (Patel and Myat, 2013)
        Other
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        82% of salivary glands LanB2MB04039 Gyc76C2388 transheterozygous embryos do not migrate completely.

        LanB2MB04039 Gyc76C2388 double mutants exacerbate the salivary gland invagination defect such that 25% of mutant glands fail to invaginate compared to 16% in Gyc76C2388 and 13% in LanB2MB04039 single mutant glands.

        (Patel and Myat, 2013)

        mewM6/LanB2MB04039 mutant third instar larvae show a mild but statistically significant increase in the proportion of dorsal midline ddaC dendrite length that is enclosed within the epidermis rather than attached to the ECM. The amount of enclosed dendrite seen in each heterozygote is similar to wild type.

        mys1/LanB2MB04039 mutant third instar larvae show a mild but statistically significant increase in the proportion of dorsal midline ddaC dendritic length that is enclosed within the epidermis rather than attached to the ECM. The amount of enclosed dendrite seen in each heterozygote is similar to wild type.

        (Han et al., 2012)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        LanB2MB04039
        (Han et al., 2012, Wolfstetter and Holz, 2012, Bellen, 2007.8.28)
        lanB2MB04039
        (Patel and Myat, 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)