Allele Dmel\Sod^Scer\UAS.cAa

General Information
Symbol	Dmel\Sod^Scer\UAS.cAa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Anderson	FlyBase ID	FBal0198445
Feature type	allele	Associated gene	Dmel\Sod

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Anderson et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of a Sod cDNA. (Anderson et al., 2005)
Carried in construct	P{UAS-Sod.A} (Anderson et al., 2005, Rival et al., 2009, Tuxworth et al., 2011, Dorn et al., 2011, Sun et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Lifespan patterns of Sod[Scer\UAS.cAa] overexpression using Scer\GAL4[da.G32] are not significantly different from diet-matched controls, suggesting that Sod[Scer\UAS.cAa] overexpression if not sufficient to alter the lifespan response of flies to diet. (Sun et al., 2012)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Sod^Scer\UAS.cAa, Scer\GAL4^elav-C155 is an enhancer of locomotor behavior defective phenotype of Hsap\APP^{Arctic.Scer\UAS.T:SS-nec}, Scer\GAL4^elav-C155 (Rival et al., 2009) Sod^Scer\UAS.cAa, Scer\GAL4^elav-C155 is an enhancer of locomotor behavior defective phenotype of Hsap\APP^{Scer\UAS.T:SS-nec}, Scer\GAL4^elav-C155 (Rival et al., 2009) Sod^Scer\UAS.cAa, Scer\GAL4^elav-C155 is an enhancer of short lived phenotype of Hsap\APP^{Arctic.Scer\UAS.T:SS-nec}, Scer\GAL4^elav-C155 (Rival et al., 2009)
Suppressor of
Statement Reference Sod^Scer\UAS.cAa/Scer\GAL4^GMR.PF is a suppressor \| partially of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cln3^Scer\UAS.cTa (Tuxworth et al., 2011)
NOT Suppressor of
Statement Reference Sod^Scer\UAS.cAa/Scer\GAL4^da.G32 is a non-suppressor of lethal phenotype of Scer\GAL4^da.G32, fh^{dsRNA.IR.Scer\UAS} (Anderson et al., 2005) Sod^Scer\UAS.cAa/Scer\GAL4^Mef2.PR is a non-suppressor of partially lethal - majority die phenotype of Mpk2¹, p38b^Δ25 (Vrailas-Mortimer et al., 2011)
Phenotype Manifest In
Suppressor of
Statement Reference Sod^Scer\UAS.cAa, Scer\GAL4^tin.CΔ4 is a suppressor \| partially of cardial cell \| adult stage phenotype of Marf^{miRNA.cUa.Scer\UAS}, Scer\GAL4^tin.CΔ4 (Dorn et al., 2011) Sod^Scer\UAS.cAa, Scer\GAL4^tin.CΔ4 is a suppressor \| partially of mitochondrion \| adult stage phenotype of Marf^{miRNA.cUa.Scer\UAS}, Scer\GAL4^tin.CΔ4 (Dorn et al., 2011) Sod^Scer\UAS.cAa, Scer\GAL4^tin.CΔ4 is a suppressor of adult heart phenotype of Marf^{miRNA.cUa.Scer\UAS}, Scer\GAL4^tin.CΔ4 (Dorn et al., 2011) Sod^Scer\UAS.cAa/Scer\GAL4^GMR.PF is a suppressor \| partially of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cln3^Scer\UAS.cTa (Tuxworth et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of Sod[Scer\UAS.cAa] rescues the heart tube defects (dilation and impaired shortening) seen in adults expressing Marf[miRNA.cUa.Scer\UAS] under the control of Scer\GAL4[tin.CΔ4]. In addition, the morphology of the mitochondria in the cardiomyocytes is markedly improved towards wild type. (Dorn et al., 2011) Co-expression of Sod[Scer\UAS.cAa] under the control of Scer\GAL4[GMR.PF] almost completely suppresses the cln3[Scer\UAS.cTa]-overexpression phenotype in the eye. (Tuxworth et al., 2011) Expression of Sod[Scer\UAS.cAa] under the control of Scer\GAL4[Mef2.PR] does not rescue the reduced viability seen in p38b[Δ25] Mpk2[1] double mutants. (Vrailas-Mortimer et al., 2011)
Xenogenetic Interactions
Statement Reference Overexpression of Sod[Scer\UAS.cAa] enhances the decreased survival phenotype of flies expressing Hsap\APP[Arctic.Scer\UAS.T:nec] under the control of Scer\GAL4[elav-C155]. Overexpression of Sod[Scer\UAS.cAa] accelerates the decline in locomotor function of flies expressing Hsap\APP[Scer\UAS.T:nec] under the control of Scer\GAL4[elav-C155]. (Rival et al., 2009)
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	24750 w¹; P{UAS-Sod.A}B37 24754 w¹; P{UAS-Sod.A}B36
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Sod^Scer\UAS.cAa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Anderson
Secondary FlyBase IDs

References ( 6 )
Research paper	Sun et al., 2012, Aging Cell 11(5): 783--793 Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. [FBrf0219634] Dorn et al., 2011, Circulation Res. 108(1): 12--17 MARF and Opa1 Control Mitochondrial and Cardiac Function in Drosophila. [FBrf0212708] Tuxworth et al., 2011, Hum. Mol. Genet. 20(10): 2037--2047 The Batten disease gene CLN3 is required for the response to oxidative stress. [FBrf0213533] Vrailas-Mortimer et al., 2011, Dev. Cell 21(4): 783--795 A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila. [FBrf0216446] Rival et al., 2009, Europ. J. Neurosci. 29(7): 1335--1347 Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. [FBrf0208222] Anderson et al., 2005, Hum. Mol. Genet. 14(22): 3397--3405 RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila. [FBrf0190823]

Allele Dmel\SodScer\UAS.cAa

Allele Dmel\Sod^Scer\UAS.cAa