Allele Dmel\ATPCL^GD3552

General Information
Symbol	Dmel\ATPCL^GD3552	Species	D. melanogaster
Name		FlyBase ID	FBal0198610
Feature type	allele	Associated gene	Dmel\ATPCL

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Dickson et al., 2007.7.18) in vitro construct - RNAi (Dickson et al., 2007.7.18)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :1..306
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat. (Dickson et al., 2007.7.18)
Carried in construct	P{GD3552} (Dickson et al., 2007.7.18, Chang et al., 2011, Lim et al., 2011, Mummery-Widmer et al., 2009)
Associated Sequence Features	dsRNA-GD3552
Cytology
Phenotypic Data
Phenotypic Class
	partially lethal - majority die \| pupal stage, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009) visible, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009)
Phenotype Manifest In
	mesothoracic tergum, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009) trichogen cell \| supernumerary, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009)
Detailed Description
	Statement Reference Expression under the control of Scer\GAL4[pnr-MD237] may result in semi-lethality, depending on the insertion line used. Expression under the control of Scer\GAL4[pnr-MD237] results in loss of bristles on the notum in 0% or 10-20% of the Scer\GAL4[pnr-MD237] expression domain, depending on the insertion line used. Expression under the control of Scer\GAL4[pnr-MD237] results in duplication of bristle hairs on the notum in 0% or 0-10% of the Scer\GAL4[pnr-MD237] expression domain, depending on the insertion line used. Expression under the control of Scer\GAL4[pnr-MD237] results in the absence of 50-60% or 70-80% of the Scer\GAL4[pnr-MD237]-expressing area of the notum, depending on the insertion line used. (Mummery-Widmer et al., 2009)
External Data
Linkouts	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 3552
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference ATPCL^GD3552/Scer\GAL4^HCH.Hand is a suppressor of adult heart phenotype of eas² (Lim et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference Expression of ATPCL[GD3552] under the control of Scer\GAL4[HCH.Hand] rescues the increased heartbeat rate and constricted heart phenotypes of eas[2] flies. (Lim et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
VDRC	v30280 w¹¹¹⁸; P{GD3552}v30280 v30282 w¹¹¹⁸; P{GD3552}v30282/TM3
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts
	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 3552
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	ATPCL^GD3552
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Chang et al., 2011, PLoS Genet. 7(2): e1001288 Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model. [FBrf0213008] Lim et al., 2011, Genes Dev. 25(2): 189--200 Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. [FBrf0212844]
Supplementary material	Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]

Allele Dmel\ATPCLGD3552

Allele Dmel\ATPCL^GD3552