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General Information
Symbol
Dmel\SerRS-mGD12798
Species
D. melanogaster
Name
FlyBase ID
FBal0198630
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

1.4% of pupae expressing Aats-serGD12798 under the control of Scer\GAL4Act5C.PU hatch successfully at 25[o]C. No adults hatch at 29[o]C.

Lactate concentration is increased compared to wild type in larvae expressing Aats-serGD12798 under the control of Scer\GAL4Act5C.PU. Glycogen concentration is decreased.

Animals expressing Aats-serGD12798 under the control of Scer\GAL4nub-AC-62 (in the presence of Dcr-2Scer\UAS.cDa to enhance RNAi efficiency) show tissue damage in the wing, with a penetrance of100% at 25[o]C and 29[o]C.

Partial or total loss of the anterior crossvein is seen in 15% of flies expressing Aats-serGD12798 under the control of Scer\GAL4ptc-559.1 at 29[o]C. The L3-L4 intervein region is significantly reduced in area compared to wild type, with the reduction being due to a decrease in cell number and not in cell size.

Flies expressing Aats-serGD12798 under the control of Scer\GAL4Mef2.PU have a shortened lifespan compared to controls (half-life is reduced from 22 to 6 days). The mutant adults have reduced climbing ability compared to controls.

Adults expressing Aats-serGD12798 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in early pupal lethality or late pupal lethality.

Expression under the control of Scer\GAL4pnr-MD237 results in lethality before the pupal stage.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Aats-serGD12798
SerRS-mGD12798
Name Synonyms
Secondary FlyBase IDs
    References (8)