FB2021_01, released Feb 18, 2021

Allele: Dmel\SerRS-mGD12798

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General Information
Symbol
Dmel\SerRS-mGD12798
Species
D. melanogaster
Name
FlyBase ID
FBal0198630
Feature type
allele
Associated gene
Dmel\SerRS-m
Associated Insertion(s)
Carried in Construct
P{GD12798}
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - RNAi
(Dickson et al., 2007.7.18)
in vitro construct - regulatory fusion
(Dickson et al., 2007.7.18)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{GD12798}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UASt regulatory sequences drive expression of an inverted repeat.

      (Dickson et al., 2007.7.18)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UASt
      Encoded product / tool
      SerRS-m
      Associated Sequence Features
      dsRNA-GD12798
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  cancer
      modeled by ykiS168A.UAS.EGFP,Tag:HA
      (Yeom et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      1.4% of pupae expressing Aats-serGD12798 under the control of Scer\GAL4Act5C.PU hatch successfully at 25[o]C. No adults hatch at 29[o]C.

      Lactate concentration is increased compared to wild type in larvae expressing Aats-serGD12798 under the control of Scer\GAL4Act5C.PU. Glycogen concentration is decreased.

      Animals expressing Aats-serGD12798 under the control of Scer\GAL4nub-AC-62 (in the presence of Dcr-2Scer\UAS.cDa to enhance RNAi efficiency) show tissue damage in the wing, with a penetrance of100% at 25[o]C and 29[o]C.

      Partial or total loss of the anterior crossvein is seen in 15% of flies expressing Aats-serGD12798 under the control of Scer\GAL4ptc-559.1 at 29[o]C. The L3-L4 intervein region is significantly reduced in area compared to wild type, with the reduction being due to a decrease in cell number and not in cell size.

      Flies expressing Aats-serGD12798 under the control of Scer\GAL4Mef2.PU have a shortened lifespan compared to controls (half-life is reduced from 22 to 6 days). The mutant adults have reduced climbing ability compared to controls.

      (Guitart et al., 2013)

      Adults expressing Aats-serGD12798 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in early pupal lethality or late pupal lethality.

      (Schnorrer et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 results in lethality before the pupal stage.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Aats-serGD12798
      SerRS-mGD12798
      Name Synonyms
      Secondary FlyBase IDs
        References (9)