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General Information
Symbol
Dmel\Atg7GD11671
Species
D. melanogaster
Name
FlyBase ID
FBal0198788
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of an inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Flies expressing Atg7GD11671 under the control of Scer\GAL4Mef2.PU have similar lifespan, locomotion and mitochondrial structure as wild-type controls.
Expression of Atg7GD11671 under the control of Scer\GAL4GMR.PF results in an eye indistinguishable from wild-type.
Expression of Atg7GD11671 under the control of Scer\GAL4hs.PU results in short lived adults compared to controls
Adults expressing Atg7GD11671 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference
Enhancer of
NOT Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
NOT suppressed by
Statement
Reference
Enhancer of
NOT Enhancer of
Statement
Reference
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference
Knockdown of Atg7 through expression of Atg7GD11671 under the control of Scer\GAL4GMR.PF suppresses the AcnScer\UAS.cNa-induced rough eye phenotype.
Co-expression of Hsp27Scer\UAS.T:Ivir\HA1 does not rescue the rough eye phenotype caused by expression of Atg7GD11671 under the control of Scer\GAL4GMR.PU.
Xenogenetic Interactions
Statement
Reference
Co-expression of Atg7GD11671 partially suppresses the decreased muscle area, but not the increased apoptosis seen in flies expressing Zzzz\CTGi480.Scer\UAS.cGa under the control of Scer\GAL4hs.PU in response to heat shock.
Co-expression of Atg7GD11671 does not suppress the protective role of expression of Hsap\ATXN3Scer\UAS.WT.T:Zzzz\His6 in suppression of eye degeneration in Scer\GAL4GMR.long>Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 flies. Co-expression of Atg7GD11671 enhances eye degeneration in Scer\GAL4GMR.long>Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 flies.
The mild mosaic eye pigmentation defect caused by expression of Zzzz\CAG41Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU is enhanced by co-expression of Atg7GD11671. A rough eye phenotype is also seen. The rough eye defect caused by expression of Zzzz\CAG63Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU is not enhanced by co-expression of Atg7GD11671.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Atg7GD11671
Name Synonyms
Secondary FlyBase IDs
    References (12)