FB2025_01 , released February 20, 2025
Allele: Dmel\B52GD8690
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General Information
Symbol
Dmel\B52GD8690
Species
D. melanogaster
Name
FlyBase ID
FBal0198809
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-IR-B52
Key Links
Genomic Maps

Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression under the control of Scer\GAL41407 results in an increased number and size of GFP-positive aggregates within neuroblast lineage cells in the larval brain compared to controls (these aggregates may indicate cell death or a disturbance of internal cellular structures).

Expression of B52GD8690 under the control of Scer\GAL4da.G32 at 25[o]C results in lethality, mainly during the pupal stage, with only rare adults recovered. Third instar larvae have smaller salivary glands than normal.

Adults expressing B52GD8690 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in early larval lethality.

Expression under the control of Scer\GAL4Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control of Scer\GAL4Mef2.PR results in sarcomeres with discontinuous Z-lines in the larval body wall muscles.

Expression under the control of Scer\GAL4pnr-MD237 results in loss of bristles on the notum in 0% or 40-50% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 0% or 70-80% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 40-50% or 50-60% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Linkouts
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
B52GD8690
Name Synonyms
Secondary FlyBase IDs
    References (12)