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General Information
Symbol
Dmel\Zip71BGD2461
Species
D. melanogaster
Name
FlyBase ID
FBal0198867
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  xanthinuria
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Under normal diet conditions, the expression of Zip71BGD2461 under the control of either Scer\GAL4CG10962-NP1093 or Scer\GAL4NP3084 does not have a significant effect on the eclosion rate, but these flies exhibit significantly decreased eclosion rates when fed with zinc (but not copper, iron, or EDTA) supplemented food, as compared to control flies. Under normal or zinc-supplemented diet, third instar larvae expressing Zip71BGD2461 under the control of Scer\GAL4CG10962-NP1093 present a significant increase in the whole-body content of zinc, but not of Iron, Manganese or Copper, as compared to controls.

Ectopic expression of single copy of Zip71BGD2461 under the control of Scer\GAL4GMR.long does not produce any defects in the adult eye, when two copies of Zip71BGD2461 as well as the Scer\GAL4GMR.long driver are used the eye displays moderate loss of pigmentation, compared to the double driver control.

Adults expressing Zip71BGD2461 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The co-expression of ZnT63CKK102261 does not suppress the decreased eclosion rate exhibited by animals expressing Zip71BGD2461 under the control of Scer\GAL4CG10962-NP1093 reared in zinc-supplemented food; under normal diet conditions, the co-expression of Zip71BGD2461 and ZnT63CKK102261 under the control of Scer\GAL4CG10962-NP1093 has no significant effect on the eclosion rate, as compared to animals only expressing either Zip71BGD2461 or ZnT63CKK102261 under the control of Scer\GAL4CG10962-NP1093.

The formation of Malpighian tubule stones in third instar larvae induced by the expression of ryHMS02827 under the control of Scer\GAL4CG10962-NP1093 is suppressed by the co-expression of Zip71BGD2461.

The morphological and pigmentation defects in the adult eye seen upon expression of ZnT86DScer\UAS.cDa under the control of Scer\GAL4GMR.long do not change upon co-expression of Zip71BGD2461 RNAi.

The adult eye phenotype seen upon expression of ZnT86DScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.long can be partially modified by co-expression of Zip71BGD2461 RNAi: the morphological defects are unchanged the pigmentation loss is mildly worsened.

Xenogenetic Interactions
Statement
Reference

The co-expression of Hsap\SLC39A5Scer\UAS.cYa, but not of Hsap\SLC39A4Scer\UAS.cYa, significantly increases the eclosion rate of animals expressing Zip71BGD2461 under the control of Scer\GAL4CG10962-NP1093 when reared under zinc-supplemented diet, but not when reared under normal diet.

Complementation and Rescue Data
Comments

Expression of Zip71BGD2461 under the control of Scer\GAL4GMR.long rescues the flat eye shape and loss of pigmentation induced by Zip71BScer\UAS.T:Zzzz\FLAG expression.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
CG10006GD2461
Zip71B-RNAi 1
Zip71BGD2461
dZip71BRNAi
Name Synonyms
Secondary FlyBase IDs
    References (7)