FlyBase Allele Report: Dmel\Pi4KIIIα[GD6917]

General Information

Symbol

Dmel\Pi4KIIIα^GD6917

Species

D. melanogaster

Name

FlyBase ID

FBal0198963

Feature type

allele

Associated gene

Dmel\Pi4KIIIα

Associated Insertion(s)

Carried in Construct

P{GD6917}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD6917}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD6917

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^nSyb.PS

(Khuong et al., 2010)

mesonotum, with Scer\GAL4^pnr-MD237

(Medina-Yáñez et al., 2020)

neuromuscular junction, with Scer\GAL4^elav-C155

(Bulat et al., 2014)

synapse, with Scer\GAL4^elav-C155

(Bulat et al., 2014)

Detailed Description

Statement

Reference

Presynaptic expression of PI4KIIIalpha^GD6917 under the control of Scer\GAL4^elav-C155 causes synaptic retractions in less than 10% of synapses.

(Bulat et al., 2014)

Expression of PI4KIIIalpha^GD6917 under the control of Scer\GAL4^n-syb.PS results in neuromuscular junction overgrowth in third instar larvae.

(Khuong et al., 2010)

Adults expressing PI4KIIIα^GD6917 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

(Neely et al., 2010)

Adults expressing PI4KIIIα^GD6917 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development