FlyBase Allele Report: Dmel\fmt[GD6928]

General Information

Symbol

Dmel\fmt^GD6928

Species

D. melanogaster

Name

FlyBase ID

FBal0198975

Feature type

allele

Associated gene

Dmel\fmt

Associated Insertion(s)

Carried in Construct

P{GD6928}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD6928}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD6928

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

anterior crossvein, with Scer\GAL4^ptc.PU

(Ma et al., 2017)

Detailed Description

Statement

Reference

Expression of fmt^GD6928 under the control of Scer\GAL4^GMR.PU has no effect on adult eye morphology, whereas Scer\GAL4^ptc.PU-driven expression results in partial or complete loss of anterior crossvein in adult wings.

(Ma et al., 2017)

Adults expressing CG10289^GD6928 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in late larval lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in loss of bristles on the notum in 20-30% or 30-40% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in planar polarity defects in the orientation of bristles of the notum in 0% or 20-30% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 0% or 30-40% of the Scer\GAL4^pnr-MD237-expressing area of the notum, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

6928

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ptc.PU, fmt^GD6928 has visible | adult stage phenotype, suppressible by puc^UAS.cMa/Scer\GAL4^ptc.PU

(Ma et al., 2017)

Scer\GAL4^ptc.PU, fmt^GD6928 has visible | adult stage phenotype, suppressible | partially by bsk^DN.UAS/Scer\GAL4^ptc.PU

(Ma et al., 2017)

Scer\GAL4^ptc.PU, fmt^GD6928 has visible | adult stage phenotype, suppressible | partially by hep^NIG.4353R/Scer\GAL4^ptc.PU

(Ma et al., 2017)

Scer\GAL4^ptc.PU, fmt^GD6928 has visible | adult stage phenotype, suppressible | partially by Tak1^K46R.UAS/Scer\GAL4^ptc.PU

(Ma et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^ptc.PU, fmt^GD6928 has visible | adult stage phenotype, non-suppressible by Traf6^RNAi.UAS/Scer\GAL4^ptc.PU

(Ma et al., 2017)

Scer\GAL4^ptc.PU, fmt^GD6928 has visible | adult stage phenotype, non-suppressible by msn^TRiP.cUa/Scer\GAL4^ptc.PU

(Ma et al., 2017)

Enhancer of

Statement

Reference

fmt^GD6928/Scer\GAL4^GMR.PU is an enhancer of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Ma et al., 2017)

fmt^GD6928/Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Ma et al., 2017)

Other

Statement

Reference

PpV^GD7532, Scer\GAL4^nub.PU, fmt^GD6928 has visible | adult stage phenotype

(Ma et al., 2017)

PpV^GD7532, Scer\GAL4^nub.PU, fmt^GD6928 has abnormal size | adult stage phenotype

(Ma et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ptc.PU, fmt^GD6928 has anterior crossvein phenotype, suppressible | partially by hep^NIG.4353R/Scer\GAL4^ptc.PU

(Ma et al., 2017)

Scer\GAL4^ptc.PU, fmt^GD6928 has anterior crossvein phenotype, suppressible | partially by Tak1^K46R.UAS/Scer\GAL4^ptc.PU

(Ma et al., 2017)

Scer\GAL4^ptc.PU, fmt^GD6928 has anterior crossvein phenotype, suppressible by puc^UAS.cMa/Scer\GAL4^ptc.PU

(Ma et al., 2017)

Scer\GAL4^ptc.PU, fmt^GD6928 has anterior crossvein phenotype, suppressible | partially by bsk^DN.UAS/Scer\GAL4^ptc.PU

(Ma et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^ptc.PU, fmt^GD6928 has anterior crossvein phenotype, non-suppressible by Traf6^RNAi.UAS/Scer\GAL4^ptc.PU

(Ma et al., 2017)

Scer\GAL4^ptc.PU, fmt^GD6928 has anterior crossvein phenotype, non-suppressible by msn^TRiP.cUa/Scer\GAL4^ptc.PU

(Ma et al., 2017)

Enhancer of

Statement

Reference

fmt^GD6928/Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Ma et al., 2017)

Other

Statement

Reference

PpV^GD7532, Scer\GAL4^nub.PU, fmt^GD6928 has wing phenotype

(Ma et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The partial or complete loss of the wing anterior crossvein in flies expressing fmt^GD6928 under the control of Scer\GAL4^ptc.PU is suppressed by co-expression of puc^Scer\UAS.cMa and partially so by co-expression of bsk^DN.Scer\UAS, hep^NIG.4353R or Tak1^{K46R.Scer\UAS} but not Traf6^{dsRNA.Scer\UAS} or msn^TRiP.cUa.

Simultaneous expression of both fmt^GD6928 and PpV^GD7532 under the control of Scer\GAL4^nub.PU results in reduced adult wing size, while individual expression of either of the RNAi transgenes has no significant effect on the size of the wing relative to controls.

The small rough eye phenotype characteristic for adult flies expressing egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PU is enhanced by co-expression of fmt^GD6928.

(Ma et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v16006