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General Information
Symbol
Dmel\RIOK1GD8541
Species
D. melanogaster
Name
FlyBase ID
FBal0199513
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Scer\GAL4Ilp2.PR-mediated expression results in a significant reduction in pupal volume and the body weight of emerging adults compared to controls.

Expression of RIOK1GD8541 under the control of Scer\GAL4repo.PU has no effect on third instar larval brain size.

Expression under the control of Scer\GAL41407 results in loss of neuroblasts in the larval brain without any change in size of the remaining neuroblasts.

Expression under the control of Scer\GAL41407 results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

Expression under the control of Scer\GAL41407 results in mild defects in the shape of ganglion mother cells in the larval brain.

Expression under the control of Scer\GAL41407 results in mild defects in the shape of neuroblasts in the larval brain.

Adults expressing RIOK1GD8541 under the control of the cardioblast-specific Scer\GAL4tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

Adults expressing RIOK1GD8541 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in late larval lethality.

Expression under the control of Scer\GAL4Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control of Scer\GAL4Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.

Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 50-60% of the Scer\GAL4pnr-MD237 expression domain.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 60-70% of the Scer\GAL4pnr-MD237-expressing area of the notum.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Suppressor of
Other
Phenotype Manifest In
Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Expression of RIOK1GD8541 suppresses the increase in brain size and glial overgrowth seen when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. There are few excess glia and remaining glial cells show abnormal development. The resulting brains are smaller in size than controls, due to a reduction in both glial and neuronal cells.

Xenogenetic Interactions
Statement
Reference

Expression of RIOK1GD8541 suppresses the brain enlargement and glial overgrowth seen when Hsap\EGFRΔ.Scer\UAS is expressed under the control of Scer\GAL4repo.PU. There are few excess glia and remaining glial cells show abnormal development. The resulting brains are smaller in size than controls, due to a reduction in both glial and neuronal cells.

Expression of RIOK1GD8541 suppresses the brain enlargement and glial overgrowth seen when Hsap\EGFRΔ.Scer\UAS and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG11660GD8541
RIOK1GD8541
Name Synonyms
Secondary FlyBase IDs
    References (8)