Adults expressing α-Man-IbGD345
under the control of Scer\GAL4elav.PLu
(in the presence of Dcr-2Scer\UAS.cDa
to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR
can result in lethality by 7 days after eclosion.