FB2025_01 , released February 20, 2025
Allele: Dmel\Abca3GD3708
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General Information
Symbol
Dmel\Abca3GD3708
Species
D. melanogaster
Name
FlyBase ID
FBal0201771
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dABCA-IR997-1106
Key Links
Genomic Maps

Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
is exacerbated by enaHMS01953
is exacerbated by hpoKC202
is exacerbated by hpoKS240
is ameliorated by wtsx1
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of one or two copies of Abca3GD3708 under the control of Scer\GAL4elav.PLu leads to an increase in the active zone number at neuromuscular junctions (of muscle 4 of the A3 and A4 segment) in third instar larvae and a reduction in larval olfactory learning abilities when compared to controls.

Expression of ABCAGD3708 under the control of either Scer\GAL4GR1 or Scer\GAL4nos.UTR.T:Hsim\VP16 does not induce any nurse cell clearance defect in mutant stage 14 egg chambers and like in wild-type all the germ-line derived nurse cells have undergone programmed cell death and been cleared by this stage.

Expression of ABCAGD3708 under the control of Scer\GAL4elav.PLu leads to a significant increase in average distance between male adults (from one or two copies of ABCAGD3708) or between female adults (only from two copies of ABCAGD3708), despite no significant changes in locomotor ability, as compared to controls. Reared under 12h:12h light:dark cycles, these adults present increases in morning activity peak, in evening peak activity (including an early onset of activity), and in midday siesta activity (which are more evident if expressing from two copies than from one copy of the transgene), as compared to controls; these adult males also exhibit an increase in night time sleep if expressing from one, but not from two, transgene copy, as compared to controls.

The neuromuscular junctions of third instar larvae expressing from one or two copies of ABCAGD3708 under the control of Scer\GAL4elav.PLu exhibit a significant increase in the number of satellite boutons, but exhibit no obvious changes in the number of mature boutons, or in either the number or length of branches, as compared to controls.

Adults expressing CG1718GD3708 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Linkouts
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
ABCAGD3708
Abca3GD3708
CG1718GD3708
Name Synonyms
Secondary FlyBase IDs
    References (9)