Allele Dmel\BTBD9^GD9543

General Information
Symbol	Dmel\BTBD9^GD9543	Species	D. melanogaster
Name		FlyBase ID	FBal0202056
Feature type	allele	Associated gene	Dmel\BTBD9

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Dickson et al., 2007.7.18) in vitro construct - RNAi (Dickson et al., 2007.7.18)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :1..305
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat. (Dickson et al., 2007.7.18)
Carried in construct	P{GD9543} (Dickson et al., 2007.7.18, Mummery-Widmer et al., 2009, Freeman et al., 2012)
Associated Sequence Features	dsRNA-GD9543
Cytology
Phenotypic Data
Phenotypic Class
	sleep defective \| adult stage, with Scer\GAL4^Ddc.HL9 (Freeman et al., 2012) sleep defective \| adult stage, with Scer\GAL4^elav-C155 (Freeman et al., 2012) sleep defective \| adult stage, with Scer\GAL4^ple.PF (Freeman et al., 2012) viable, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009)
Phenotype Manifest In

Detailed Description
	Statement Reference The total duration of sleep per 24 hour period is not significantly different from wild type in flies expressing BTBD9[GD9543] under the control of either Scer\GAL4[elav-C155], Scer\GAL4[ple.PF] or Scer\GAL4[Ddc.HL9]. However, during the night the mean sleep bout length is decreased, the mean sleep bout number is increased and the amount of wake after sleep onset is increased in the mutant flies compared to wild type, indicating fragmented night-time sleep. Expression of BTBD9[GD9543] under the control of Scer\GAL4[Ddc.HL5] does not result in defects in night-time sleep in adult flies. (Freeman et al., 2012)
External Data
Linkouts	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 9543
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
VDRC	v33049 w¹¹¹⁸; P{GD9543}v33049/CyO
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts
	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 9543
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	BTBD9^GD9543 CG1826^GD9543
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Freeman et al., 2012, Curr. Biol. 22(12): 1142--1148 Sleep fragmentation and motor restlessness in a Drosophila model of restless legs syndrome. [FBrf0218705]
Supplementary material	Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]

Allele Dmel\BTBD9GD9543

Allele Dmel\BTBD9^GD9543