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General Information
Symbol
Dmel\dsbGD2254
Species
D. melanogaster
Name
FlyBase ID
FBal0202182
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Simultaneous expression of dsbGD2254 and dsbKK107147 under the control of either Scer\GAL4MJ12a or Scer\GAL4grh.D4 leads to dorsal trunk elongation defects and internalization of the posterior spiracles into the body cavity. Most larvae survive until third instar larval stage and show a moderate growth reduction. Scer\GAL4btl.PS-driven expression does not result in any visible phenotype. Individual expression of dsbGD2254 controlled by Scer\GAL4grh.D4 also results in impaired dorsal trunk elongation and in partial lethality.

Expression of dsbGD2254 in posterior epidermal cells under the control of Scer\GAL4en-e16E prevents phagocytic clearance of ddaC neuron dendrite debris following pupal stage dendritic pruning. Similarly, when larval dendrites are injured (severed with an infrared laser) expression of dsbGD2254 under the control of Scer\GAL4A58 and Scer\GAL4I-76-D blocks dendritic debris clearance.

Adults expressing dsbGD2254 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG1887GD2254
dsbGD2254
Name Synonyms
Secondary FlyBase IDs
    References (8)