FB2025_01 , released February 20, 2025
Allele: Dmel\ReepAGD2168
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General Information
Symbol
Dmel\ReepAGD2168
Species
D. melanogaster
Name
FlyBase ID
FBal0202508
Feature type
allele
Associated gene
Dmel\ReepA
Associated Insertion(s)
Carried in Construct
P{GD2168}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD2168}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD2168
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.2N4R.cAa
      (Appocher et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Scer\GAL4GMR.PU>Reep1GD2168 alone does not produce apparent defects in the retinas.

      (Appocher et al., 2014)

      Adults expressing Reep1GD2168 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      ReepAGD2168, Scer\GAL4GMR.PU is an enhancer of eye phenotype of Hsap\MAPTUAS.2N4R.cAa, Scer\GAL4GMR.PU

      (Appocher et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Scer\GAL4GMR.PU>Reep1GD2168 strongly enhances the neurodegeneration induced by Hsap\MAPTScer\UAS.2N4R.cAa expression. As a result of the enhanced neurotoxic effects, the surface area of the eye is further reduced and becomes more disorganised.

      (Appocher et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG30193GD2168
      CG42678GD2168
      Reep1GD2168
      ReepAGD2168
      Name Synonyms
      Secondary FlyBase IDs
        References (7)