Allele Dmel\trpm^GD4541

General Information
Symbol	Dmel\trpm^GD4541	Species	D. melanogaster
Name		FlyBase ID	FBal0203795
Feature type	allele	Associated gene	Dmel\trpm

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms lethal
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Dickson et al., 2007.7.18) in vitro construct - RNAi (Dickson et al., 2007.7.18)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :186..313 :1..185
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat. (Dickson et al., 2007.7.18)
Carried in construct	P{GD4541} (Dickson et al., 2007.7.18, Georgiev et al., 2010, Mummery-Widmer et al., 2009, Tsubouchi et al., 2012)
Associated Sequence Features	dsRNA-GD4541
Cytology
Phenotypic Data
Phenotypic Class
	decreased cell size, with Scer\GAL4^AB1 (Georgiev et al., 2010) lethal, with Dcr-2^Scer\UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW (Tsubouchi et al., 2012) viable, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009)
Phenotype Manifest In
	mitochondrion, with Scer\GAL4^34B (Georgiev et al., 2010) salivary gland, with Scer\GAL4^AB1 (Georgiev et al., 2010)
Detailed Description
	Statement Reference Expression of trpm[GD4541] under the control of Scer\GAL4[AB1] results in a reduction in size of the salivary gland cells, while the size of fat body cells is unaffected. Mitochondria in salivary glands of animals expressing trpm[GD4541] under the control of Scer\GAL4[34B] are fused to form long tubular structures (in wild type they are seen as individual bullet-shaped structures). (Georgiev et al., 2010)
External Data
Linkouts	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 4541
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
VDRC	v30609 w¹¹¹⁸; P{GD4541}v30609 v30610 w¹¹¹⁸; P{GD4541}v30610
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts
	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 4541
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG34123^GD4541 trpm^GD4541
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Georgiev et al., 2010, Cell Metab. 12(4): 386--397 TRPM Channels Mediate Zinc Homeostasis and Cellular Growth during Drosophila Larval Development. [FBrf0211938]
Supplementary material	Tsubouchi et al., 2012, Curr. Biol. 22(22): Tables S1 and S2. RNAi Lines Tested for Screening and Candidate Channel Genes, Related to Figure 5. [FBrf0220657] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]

Allele Dmel\trpmGD4541

Allele Dmel\trpm^GD4541