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General Information
Symbol
Dmel\scribGD11666
Species
D. melanogaster
Name
FlyBase ID
FBal0204693
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-scrib-IR
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing scribGD11666 under the control of Scer\GAL4ptc.PU induces some cells at the wing disc A/P boundary to delaminate and migrate to the posterior compartment.

Expressing scribGD11666 at the anterior/posterior boundary of the third instar larval wing disc (under the control of Scer\GAL4ptc-559.1) leads to severe cell migration away from the ptc-positive domain.

Expression of scribGD11666 under the control of Scer\GAL4Hml.Δ does not lead to a significant difference in survival as compared to controls when larvae are infected with the nematode Heterorhabditis bacteriophora and its associated bacterium Photorhabdus luminescens.

Expression of scribGD11666 under the control of Scer\GAL4ple.PF or Scer\GAL4GMR13F02 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) results in enhanced memory after conditioning in an olfactory conditioning assay.

scribGD11666-expressing clones in the wing or eye disc do not survive.

When scribGD11666 is expressed along the anterior/posterior (A/P) compartment boundary of wing imaginal discs under the control of Scer\GAL4ptc.PU, cells delaminate and migrate away from the (A/P boundary).

Down-regulation of scrib along the anterior/posterior compartment boundary, through expression of scribGD11666 under the control of Scer\GAL4ptc-559.1, produces a JNK-dependent invasion-like phenotype, in which cells delaminate and migrate away posteriorly.

Adults expressing scribGD11666 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies or late larval lethality.

Expression under the control of Scer\GAL4pnr-MD237 may result in lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 30-40% of the Scer\GAL4pnr-MD237-expressing area of the notum.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of benGD1387 suppresses the cell migration seen when scribGD11666 is expressed along the anterior/posterior (A/P) compartment boundary of wing imaginal discs under the control of Scer\GAL4ptc.PU.

One copy of ben1 suppresses the cell migration seen when scribGD11666 is expressed along the anterior/posterior (A/P) compartment boundary of wing imaginal discs under the control of Scer\GAL4ptc.PU.

Loss of Uev1A, through co-expression of Uev1AGD6650, significantly suppresses the epithelial migration phenotype found in flies expressing scribGD11666 under the control of Scer\GAL4ptc-559.1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG5467GD11666
scribGD11666
Name Synonyms
Secondary FlyBase IDs
    References (12)