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General Information
Symbol
Dmel\barcGD9921
Species
D. melanogaster
Name
FlyBase ID
FBal0204932
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of barcGD9921 under the control of Scer\GAL4insc-Mz1407 leads to a significant increase in the number of intermediate neural progenitors, namely of immature Ase-positive, Dpn-negative intermediates, and to significant decreases in the numbers of ganglion mother cells and of Pros-positive neurons in type II neuroblast lineages, as compared to controls. This expression also leads to significant increases in the cell size of type I and type II neuroblasts, intermediate neural progenitors, and ganglion mother cells, as compared to controls. Expression under the control of either Scer\GAL4ase.neuro or Scer\GAL4insc-Mz1407 leads to a significant decrease in the number of neuroblasts and to the converse significant increase in the number of ganglion mother cells in type I neuroblast lineages, as compared to controls.

Individuals expressing barcGD9921 under the control of Scer\GAL4pnt-14-94 are viable and reach adulthood. This expression leads to adult brains exhibiting severe neuroanatomical defects in the central complex (the ellipsoid body, fan-shaped body, and nodoli are all deformed) and exhibiting a decrease in the number of type II neuroblast-derived neurons, as compared to controls.

The expression of barcGD9921 leads to a significant decrease in the division rates of type II neuroblasts and intermediate neural progenitors (under the combined control of Scer\GAL4wor.PA, Scer\GAL80ase.PN) and of type I neuroblasts and ganglion mother cells (under the control of Scer\GAL4ase.neuro alone), as shown by their shorter cell cycle time and their higher proportion of cells in G2/M compared to controls.

Expression under the control of Scer\GAL41407 results in an increase in the number of neuroblasts in the larval brain compared to controls.

Expression under the control of Scer\GAL41407 results in longer neuroblast lineages (more daughter cells per neuroblast) in the larval brain compared to controls.

Expression under the control of Scer\GAL41407 results in mild defects in the shape of ganglion mother cells in the larval brain.

Expression under the control of Scer\GAL41407 results in an increase in the average size of ganglion mother cells in the larval brain compared to controls.

Adults expressing barcGD9921 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in adult/pharate lethality.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 100% of the Scer\GAL4pnr-MD237-expressing area of the notum.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG6049GD9921
barcGD9921
Name Synonyms
Secondary FlyBase IDs
    References (7)