FB2025_01 , released February 20, 2025
Allele: Dmel\Vha16-5GD1075
Open Close
General Information
Symbol
Dmel\Vha16-5GD1075
Species
D. melanogaster
Name
FlyBase ID
FBal0205190
Feature type
allele
Associated gene
Dmel\Vha16-5
Associated Insertion(s)
Carried in Construct
P{GD1075}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD1075}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD1075
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Vha16-5GD1075 under the control of Scer\GAL4nub.PU (together with Dicer-2, for efficient RNAi) leads to blistered wings of abnormal size, as compared to controls.

      (Hevia et al., 2017)

      Adults expressing Vha16-5GD1075 under the control of the cardioblast-specific Scer\GAL4tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

      (Neely et al., 2010)

      Adults expressing Vha16-5GD1075 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies or adult/pharate lethality.

      (Schnorrer et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 results in a colour difference between the central Scer\GAL4pnr-MD237 expression domain of the notum and the surrounding lateral region in 0%, 30-40% or 100% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

      Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 0% or 10-20% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scer\GAL4nub.PU/Vha16-5GD1075 is a suppressor of wing phenotype of Scer\GAL4nub.PU, SmoxSDVD.UAS

      (Hevia et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of Vha16-5GD1075 (together with Dicer-2, for efficient RNAi) suppresses the oversized wing defects induced by the expression of SmoxSDVD.Scer\UAS under the control of Scer\GAL4nub.PU.

      (Hevia et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG6737GD1075
      Vha16-5GD1075
      Name Synonyms
      Secondary FlyBase IDs
        References (7)