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General Information
Symbol
Dmel\Vps4GD12054
Species
D. melanogaster
Name
FlyBase ID
FBal0205226
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of an inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Adults expressing Vps4GD12054 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in early pupal lethality or late larval lethality. Expression under the control of Scer\GAL4Mef2.PR results in grossly normal larval body wall muscles. Expression under the control of Scer\GAL4Mef2.PR results in sarcomeres with reduced Z-lines in the larval body wall muscles.
Expression under the control of Scer\GAL4pnr-MD237 results in lethality (either before or at the pupal stage), depending on the insertion line used.
Expression of Vps4GD12054 under the control of Scer\GAL4Bx-MS1096-KE results in disruption of the actin cytoskeleton in wing imaginal disc cells. Larvae expressing Vps4GD12054 under the control of Scer\GAL4Bx-MS1096-KE continue to grow beyond the normal time of growth termination, become oversized and die shortly after delayed pupation. Wing discs expressing Vps4GD12054 under the control of Scer\GAL4Bx-MS1096-KE form enlarged tubular structures which contain internal vesicles when characterised ultrastructurally (these structures are not seen in control discs). These structures are often irregular in shape and sometimes occupy most of the cell volume.
External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG6842GD12054
Vps4GD12054
Name Synonyms
Secondary FlyBase IDs
    References (10)