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General Information
Symbol
Dmel\HHEXGD4293
Species
D. melanogaster
Name
FlyBase ID
FBal0205311
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Unlike controls, larvae expressing HHEXGD4293 under the control of Scer\GAL4αTub84B.PL are intolerant to high levels of dietary sucrose or 0.1M glucosamine, and fail to pupariate. Raising these animals on a high salt diet has a similar effect. However, these animals show a similar response to controls when raised on other diets, including diets containing hydrogen peroxide, silver nitrate, or high fat.

Expression of HHEXGD4293 under the control of Scer\GAL4tin.cBa (together with Scer\GAL4Scer\UAS.cHa), Scer\GAL4srp.Hemo, Scer\GAL4sns.GCN, Scer\GAL4byn-Gal4, Scer\GAL4Myo31DF-NP0001, Scer\GAL4Ilp2.PR or Scer\GAL4Cg.PA does not affect the viability of larvae fed a high sucrose diet. In contrast, expression of HHEXGD4293 via Scer\GAL4esg-05730B or Scer\GAL4Dot.PK does decrease survival to eclosion in a sugar-sensitive manner, and expression via Scer\GAL4esg-05730B also decreases survival to pupariation in a sugar-sensitive manner.

Scer\GAL4Cg.PA-mediated expression of HHEXGD4293, together with Dcr-2Scer\UAS.cDa, in the presence of high (1.0M) sucrose, is male lethal. Both larval and adult female flies are significantly smaller than controls; wandering third instar larvae are hyperglycemic; both adults and larvae have significantly lower triglyceride levels compared to controls.

Expression under the control of Scer\GAL41407 results in a reduction in the average size of neuroblasts together with shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

Adults expressing HHEXGD4293 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies or early pupal lethality.

Expression under the control of Scer\GAL4pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in a colour difference between the central Scer\GAL4pnr-MD237 expression domain of the notum and the surrounding lateral region in 0% or 10-20% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 0-10% or 20-30% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 0-10% or 80-90% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG7056GD4293
HHEXGD4293
Name Synonyms
Secondary FlyBase IDs
    References (7)