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General Information
Symbol
Dmel\BI-1GD1660
Species
D. melanogaster
Name
FlyBase ID
FBal0205365
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

At 6 hours after puparium formation, pupae expressing BI-1GD1660 (together with Dcr-2Scer\UAS.cDa) under the control of Scer\GAL4da.G32 exhibit faster elimination of salivary gland cells, which is associated with enhanced cell shrinkage and a decreased and disorganized action cytoskeleton, compared to controls.

Larvae expressing BI-1GD1660 under the control of Scer\GAL4da.G32 exhibit an augmentation in the number of autophagosomes and lysosomes in the fat body of fasting larvae.

A substantial extension of lifespan is observed during nutrient starvation when BI-1GD1660 is expressed under the control of Scer\GAL4da.G32.

Treatment of BI-1GD1660 Scer\GAL4da.G32 animals with tunicamycin (an ER stress agent) results in decreased survival, whereas the same treatment of control flies has no effect on lifespan.

Adults expressing BI-1GD1660 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
BI-1GD1660
CG7188GD1660
Name Synonyms
Secondary FlyBase IDs
    References (6)