FlyBase Allele Report: Dmel\Megf8[GD2634]

General Information

Symbol

Dmel\Megf8^GD2634

Species

D. melanogaster

Name

FlyBase ID

FBal0205489

Feature type

allele

Associated gene

Dmel\Megf8

Associated Insertion(s)

Carried in Construct

P{GD2634}

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - RNAi

(Dickson et al., 2007.7.18)

in vitro construct - regulatory fusion

(Dickson et al., 2007.7.18)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{GD2634}

Cytology

Nature of the lesion

Statement

Reference

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Megf8

Associated Sequence Features

dsRNA-GD2634

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^Act5C.PI

(Lloyd et al., 2018)

lethal, with Scer\GAL4^αTub84B.PL

(Lloyd et al., 2018)

partially lethal - majority die, with Scer\GAL4^btl.PS

(Lloyd et al., 2018)

partially lethal - majority die, with Scer\GAL4^how-24B

(Lloyd et al., 2018)

planar polarity defective | adult stage, with Scer\GAL4^Act5C.PI

(Lloyd et al., 2018)

size defective | adult stage, with Scer\GAL4^Act5C.PI

(Lloyd et al., 2018)

small body | adult stage, with Scer\GAL4^Act5C.PI

(Lloyd et al., 2018)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Bx-MS1096

(Lloyd et al., 2018)

viable, with Scer\GAL4^Dll.PU

(Lloyd et al., 2018)

viable, with Scer\GAL4^elav-C155

(Lloyd et al., 2018)

viable, with Scer\GAL4^GMR.PU

(Lloyd et al., 2018)

viable, with Scer\GAL4^Mef2.PR

(Lloyd et al., 2018, Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^Sgs3.PD

(Lloyd et al., 2018)

Phenotype Manifest In

abdominal segment, with Scer\GAL4^Act5C.PI

(Lloyd et al., 2018)

adult abdominal sensillum, with Scer\GAL4^Act5C.PI

(Lloyd et al., 2018)

Detailed Description

Statement

Reference

The few escapers from the expression of Megf8^GD2634 under the control of Scer\GAL4^Act5C.PI show small body size, narrow abdominal segments, and planar polarity defects, as shown by the defective number and orientation of abdominal sensory bristles, as compared to controls.

(Lloyd et al., 2018)

Adults expressing CG7466^GD2634 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 0% or 0-10% of the Scer\GAL4^pnr-MD237-expressing area of the notum, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2634

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v8018

w¹¹¹⁸ P{GD2634}v8018

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Crossreferences

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2634

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG7466^GD2634

Megf8^GD2634

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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