FlyBase Allele Report: Dmel\anchor[GD3613]

Expression of anchor^GD3613 under the control of Scer\GAL4^hs.PU, induced by daily heat shock from third instar stage, or under the control of Scer\GAL4^A9 or Scer\GAL4^Bx-MS1096, results in thicker wing veins and an increased number of wing veins compared with controls. Scer\GAL4^Bx-MS1096-driven expression additionally causes wing discs to be larger in the larva. Scer\GAL4^A9-driven expression additionally causes significant increases in the size and cell proliferation rate of the wing blade region of the larval wing disc, and adult wing size, compared to controls. This expression also increases the width of the dorsal-ventral boundary stripe in the wing disc.

Expression of anchor^GD3613 under the control of Scer\GAL4^dpp.blk1 results in thicker wing veins and an increased number of wing veins in the anterior-posterior boundary compared with controls; these flies also have an increased distance between L3 and L4 wing veins than controls.

Expression of anchor^GD3613 under the control of Scer\GAL4^en-e16E results in thicker wing veins and an increased number of wing veins in the adult wing posterior compartment compared with controls; the larval posterior wing disc has increased cell division (PH3 staining).

Expression of anchor^GD3613 under the control of Scer\GAL4^nub.PU, in combination with a Gal80[ts] transgene to restrict expression to a particular developmental period, can cause defects in the adult wings; expression for 48 hours during the larval stage results in wing overgrowth with no wing vein phenotype; expression for 24 hours during the pupal stage results in extra wing veins with no wing size phenotype.

(Wang et al., 2018)

Adults expressing CG7510^GD3613 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in late larval lethality.

Expression under the control of Scer\GAL4^Mef2.PR results in split larval body wall muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in semi-lethality before the pupal stage.

Expression under the control of Scer\GAL4^pnr-MD237 results in an enlarged notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

3613

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, enhanceable by Scer\GAL4^A9/gbb^UAS.cUa

(Wang et al., 2018)

Suppressed by

Statement

Reference

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, suppressible | partially by Med^JF02218, Scer\GAL4^A9

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, suppressible | partially by Med^JF02218, Scer\GAL4^A9

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, suppressible | partially by Mad^RNAi.UAS.cUa, Scer\GAL4^A9

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, suppressible | partially by Mad^RNAi.UAS.cUa, Scer\GAL4^A9

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, suppressible | partially by Mad¹²/Mad[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, suppressible | partially by Mad¹²/Mad[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, suppressible | partially by tkv⁷/tkv[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, suppressible | partially by tkv⁷/tkv[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, suppressible | partially by tkv[+]/tkv⁴²⁷

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, suppressible | partially by tkv[+]/tkv⁴²⁷

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, suppressible | partially by sax⁴/sax[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, suppressible | partially by sax⁴/sax[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, suppressible | partially by Scer\GAL4^A9/sax^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^A9/sax^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, suppressible | partially by Scer\GAL4^A9/gbb^HMS01243

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^A9/gbb^HMS01243

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, suppressible by Scer\GAL4^A9/put^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^A9/put^RNAi.UAS.cUa

(Wang et al., 2018)

NOT suppressed by

Statement

Reference

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, non-suppressible by N^Mcd8

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, non-suppressible by N^Mcd8

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype, non-suppressible by Egfr^GD1654, Scer\GAL4^A9

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype, non-suppressible by Egfr^GD1654, Scer\GAL4^A9

(Wang et al., 2018)

Enhancer of

Statement

Reference

Scer\GAL4^A9/anchor^GD3613 is an enhancer of visible | adult stage phenotype of Scer\GAL4^A9, gbb^UAS.cUa

(Wang et al., 2018)

Suppressor of

Statement

Reference

anchor^GD3613, Scer\GAL4^A9 is a suppressor | partially of abnormal size | adult stage phenotype of Med^JF02218, Scer\GAL4^A9

(Wang et al., 2018)

anchor^GD3613, Scer\GAL4^A9 is a suppressor | partially of visible | adult stage phenotype of Med^JF02218, Scer\GAL4^A9

(Wang et al., 2018)

anchor^GD3613, Scer\GAL4^A9 is a suppressor | partially of abnormal size | adult stage phenotype of Mad^RNAi.UAS.cUa, Scer\GAL4^A9

(Wang et al., 2018)

anchor^GD3613, Scer\GAL4^A9 is a suppressor | partially of visible | adult stage phenotype of Mad^RNAi.UAS.cUa, Scer\GAL4^A9

(Wang et al., 2018)

Scer\GAL4^A9/anchor^GD3613 is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^A9, dpp^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9/anchor^GD3613 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^A9, dpp^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9/anchor^GD3613 is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4^A9, gbb^HMS01243

(Wang et al., 2018)

Scer\GAL4^A9/anchor^GD3613 is a suppressor of visible | adult stage phenotype of Scer\GAL4^A9, gbb^HMS01243

(Wang et al., 2018)

Other

Statement

Reference

Mad¹², Scer\GAL4^A9, anchor^GD3613 has visible | adult stage phenotype

(Wang et al., 2018)

Mad¹², Scer\GAL4^A9, anchor^GD3613 has abnormal size | adult stage phenotype

(Wang et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^A9, anchor^GD3613 has wing vein | increased number phenotype, enhanceable by Scer\GAL4^A9/gbb^UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, enhanceable by Scer\GAL4^A9/gbb^UAS.cUa

(Wang et al., 2018)

Suppressed by

Statement

Reference

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, suppressible | partially by Mad¹²/Mad[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing phenotype, suppressible | partially by Mad¹²/Mad[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, suppressible | partially by tkv⁷/tkv[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing phenotype, suppressible | partially by tkv⁷/tkv[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, suppressible | partially by tkv[+]/tkv⁴²⁷

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing phenotype, suppressible | partially by tkv[+]/tkv⁴²⁷

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, suppressible | partially by sax⁴/sax[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing phenotype, suppressible | partially by sax⁴/sax[+]

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, suppressible | partially by Scer\GAL4^A9/sax^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing phenotype, suppressible | partially by Scer\GAL4^A9/sax^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, suppressible | partially by Scer\GAL4^A9/gbb^HMS01243

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing phenotype, suppressible | partially by Scer\GAL4^A9/gbb^HMS01243

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing phenotype, suppressible | partially by Scer\GAL4^A9/put^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing phenotype, suppressible | partially by Scer\GAL4^A9/dpp^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, suppressible | partially by Med^JF02218, Scer\GAL4^A9

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, suppressible | partially by Mad^RNAi.UAS.cUa, Scer\GAL4^A9

(Wang et al., 2018)

NOT suppressed by

Statement

Reference

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, non-suppressible by N^Mcd8

(Wang et al., 2018)

Scer\GAL4^A9, anchor^GD3613 has wing vein phenotype, non-suppressible by Egfr^GD1654, Scer\GAL4^A9

(Wang et al., 2018)

Enhancer of

Statement

Reference

Scer\GAL4^A9/anchor^GD3613 is an enhancer of wing vein | increased number phenotype of Scer\GAL4^A9, gbb^UAS.cUa

(Wang et al., 2018)

Suppressor of

Statement

Reference

anchor^GD3613, Scer\GAL4^A9 is a suppressor | partially of wing phenotype of Med^JF02218, Scer\GAL4^A9

(Wang et al., 2018)

anchor^GD3613, Scer\GAL4^A9 is a suppressor | partially of wing phenotype of Mad^RNAi.UAS.cUa, Scer\GAL4^A9

(Wang et al., 2018)

Scer\GAL4^A9/anchor^GD3613 is a suppressor | partially of wing phenotype of Scer\GAL4^A9, dpp^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9/anchor^GD3613 is a suppressor of wing vein phenotype of Scer\GAL4^A9, gbb^HMS01243

(Wang et al., 2018)

Scer\GAL4^A9/anchor^GD3613 is a suppressor of wing phenotype of Scer\GAL4^A9, gbb^HMS01243

(Wang et al., 2018)

NOT Suppressor of

Statement

Reference

Scer\GAL4^A9/anchor^GD3613 is a non-suppressor of wing vein phenotype of Scer\GAL4^A9, dpp^RNAi.UAS.cUa

(Wang et al., 2018)

Scer\GAL4^A9/anchor^GD3613 is a non-suppressor of wing vein phenotype of Scer\GAL4^A9, put^RNAi.UAS.cUa

(Wang et al., 2018)

Other

Statement

Reference

Mad¹², Scer\GAL4^A9, anchor^GD3613 has wing phenotype

(Wang et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The thickened wing vein phenotype of adults expressing anchor^GD3613 under the control of Scer\GAL4^A9 is partially suppressed by addition of Med^JF02218, Mad^TRiP.cUa, Mad¹²/+, tkv⁷/+, tkv⁴²⁷/+, sax⁴/+, sax^TRiP.cUa or gbb^HMS01243, but not N^Mcd8 or Egfr^GD1654.

The increased wing size phenotype of adults expressing anchor^GD3613 under the control of Scer\GAL4^A9 is suppressed by addition of put^TRiP.cUa, gbb^HMS01243, Mad¹²/+ or dpp^TRiP.cUa, but not sax⁴/+, tkv⁷/+ or tkv⁴²⁷/+. In the cases of Mad¹²/+ and dpp^TRiP.cUa, size is reduced to the extent that it is decreased compared to flies with Scer\GAL4^A9 driver alone.

The decreased wing size phenotype of adults expressing Med^JF02218 or Mad^TRiP.cUa under the control of Scer\GAL4^A9 is suppressed by addition of anchor^GD3613.

Additional expression of anchor^GD3613 in flies expressing dpp^TRiP.cUa under the control of Scer\GAL4^A9 does not rescue the reduction in wing vein tissue, but does slightly rescue wing size.

(Wang et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

anchor^GD3613 is partially rescued by Scer\GAL4^A9/anchor^UAS.cWa

(Wang et al., 2018)

anchor^GD3613 is partially rescued by Scer\GAL4^A9/anchor^G9098

(Wang et al., 2018)

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