The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing ND-42ninaE.GD6220 is not suppressed by Scer\GAL454C-driven (glial) expression of SlnGD1940 while expression under the control of the neuronal Scer\GAL4elav.PLu driver efficiently rescues the phenotype.
Expression of SlnGD1940 in the ey>flip whole-eye clones mutant for either sicilyE or MarfB ameliorates the lipid droplet accumulation in retinal glial cells in adult flies and also improves the photoreceptor degeneration phenotype.
The accumulation of lipid droplets in the retinal glia of adult flies expressing either SREBPUAS.cKa or bskScer\UAS.cBa under the control of Scer\GAL4nSyb.PS is significantly suppressed by co-expression of SlnGD1940.
Adults expressing SlnGD1940 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies or late pupal lethality.