FlyBase Allele Report: Dmel\ZnT49B[GD1962]

General Information

Symbol

Dmel\ZnT49B^GD1962

Species

D. melanogaster

Name

FlyBase ID

FBal0205942

Feature type

allele

Associated gene

Dmel\ZnT49B

Associated Insertion(s)

Carried in Construct

P{GD1962}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1962}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1962

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of adult locomotory behavior, with Scer\GAL4^69B

(Ge et al., 2024)

decreased rate of adult locomotory behavior, with Scer\GAL4^da.G32

(Ge et al., 2024)

partially lethal, with Scer\GAL4^da.G32

(Ge et al., 2024)

short lived, with Scer\GAL4^da.G32

(Ge et al., 2024)

some die during P-stage, with Scer\GAL4^da.G32

(Ge et al., 2024)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible | adult stage, with Scer\GAL4^da.G32

(Ge et al., 2024)

Phenotype Manifest In

mitochondrial crista, with Scer\GAL4^da.G32

(Ge et al., 2024)

mitochondrion, with Scer\GAL4^da.G32

(Ge et al., 2024)

trichogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

wing, with Scer\GAL4^da.G32

(Ge et al., 2024)

Detailed Description

Statement

Reference

Adults expressing ZnT49B^GD1962 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 60-70% or 90-100% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1962

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^69B, ZnT49B^GD1962 has decreased rate of adult locomotory behavior phenotype, suppressible | partially by SCaMC^GD14864, Scer\GAL4^69B

(Ge et al., 2024)

Scer\GAL4^69B, ZnT49B^GD1962 has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Mmus\Slc30a9^UAS.cGa, Scer\GAL4^69B

(Ge et al., 2024)

Enhancer of

Statement

Reference

ZnT49B^GD1962/Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

ZnT49B^GD1962/Scer\GAL4^GMR.long is an enhancer of abnormal eye color phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

NOT Suppressor of

Statement

Reference

ZnT49B^GD1962/Scer\GAL4^GMR.long is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

ZnT49B^GD1962/Scer\GAL4^GMR.long is a non-suppressor of abnormal eye color phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

ZnT49B^GD1962/Scer\GAL4^GMR.long is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

ZnT49B^GD1962/Scer\GAL4^GMR.long is a non-suppressor of abnormal eye color phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

ZnT49B^GD1962/Scer\GAL4^GMR.long is an enhancer of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

NOT Suppressor of

Statement

Reference

ZnT49B^GD1962/Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

ZnT49B^GD1962/Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The morphological and pigmentation defects in the adult eye seen upon expression of ZnT86D^Scer\UAS.cDa under the control of Scer\GAL4^GMR.long are mildly exacerbated by co-expression of ZnT49B^GD1962 RNAi.

The morphological and pigmentation defects in the adult eye seen upon expression of ZnT86D^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.long do not change upon co-expression of ZnT49B^GD1962 RNAi.

The morphological and pigmentation defects in the adult eye seen upon expression of Zip71B^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.long do not change upon co-expression of ZnT49B^GD1962 RNAi.

(Dechen et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v4654

w¹¹¹⁸; P{GD1962}v4654

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1962

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG8632^GD1962

ZnT49B^GD1962

dZnT49B^RNAi

(Dechen et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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