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General Information
Symbol
Dmel\Lrp4GD14320
Species
D. melanogaster
Name
FlyBase ID
FBal0206035
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Lrp4GD14320 results in the decreased synapse number (assessed by counting active zone marker puncta) in the VA1v olfactory receptor neurons (with the Scer\GAL4peb-GAL4 driver) or excitatory projection neurons terminating in the lateral horn (with Scer\GAL4Mz19) but not in Gad1-positive inhibitory neurons (with the Scer\GAL4Gad1.3.098 driver) or in the inhibitory projection neurons terminating in the lateral horn (with Scer\GAL4Mz699), while the neurite volume remains unaffected compared to controls in all cases.

Scer\GAL4peb-GAL4-driven expression of Lrp4GD14320 also results in complete loss of olfactory attraction of adult flies to an attractive odorant (apple cider vinegar) in a trap assay. This lack of olfactory attraction behavior is not due to general defects in locomotion.

Expression of CG8909GD14320 under the control of Scer\GAL4sal.BO (in combination with a Dicer-2 transgene to enhance RNAi efficiency) does not result in larval lethality at the L2/L3 transition.

Expression under the control of Scer\GAL41407 results in an increased number of GFP-positive aggregates within neuroblast lineage cells in the larval brain compared to controls (these aggregates may indicate cell death or a disturbance of internal cellular structures).

Adults expressing CG8909GD14320 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The loss of olfactory attraction behavior in response to an attractive odorant (apple cider vinegar) in adult flies expressing Lrp4GD14320 under the control of Scer\GAL4peb-GAL4 is ameliorated by co-expression of Srpk79DScer\UAS.T:Avic\GFP-YFP.Venus.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG8909GD14320
Lrp4GD14320
Name Synonyms
Secondary FlyBase IDs
    References (9)