FB2025_01 , released February 20, 2025
Allele: Dmel\ND-51GD5335
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General Information
Symbol
Dmel\ND-51GD5335
Species
D. melanogaster
Name
FlyBase ID
FBal0206119
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Compared to one parental control (though not the other), expression of ND51GD5335 via Scer\GAL4elav-C155 causes increased agressive behaviour (lunging assay) in 4-6 day-old male flies. Expression via Scer\GAL4repo does not cause increased agressive behaviour.

Adults expressing ND-51GD5335 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression of CG9140GD5335 under the control of Scer\GAL4da.Switch.PT in the presence of 20μ/ml RU486 results in lethality.

Expression of CG9140GD5335 under the control of Scer\GAL4da.Switch.PT in the presence of 1μ/ml RU486 results in a prolonged developmental phase compared to controls.

Expression of CG9140GD5335 under the control of Scer\GAL4da.Switch.PT in the presence of 1μ/ml RU486 does not result in a significant change in body weight in male flies.

Expression of CG9140GD5335 under the control of Scer\GAL4da.Switch.PT in the presence of 1μ/ml RU486 does not have a significant effect on adult lifespan.

Expression under the control of Scer\GAL4Mef2.PR results in early pupal lethality.

Expression under the control of Scer\GAL4pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in loss of bristles on the notum in 0% or 20-30% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 70-80% or 80-90% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 20-30% of the Scer\GAL4pnr-MD237-expressing area of the notum.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Linkouts
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
CG9140GD5335
CG9140v43183
ND-51GD5335
ND51GD5335
Name Synonyms
Secondary FlyBase IDs
    References (9)