FB2025_01 , released February 20, 2025
Allele: Dmel\EogtGD5084
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General Information
Symbol
Dmel\EogtGD5084
Species
D. melanogaster
Name
FlyBase ID
FBal0206387
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of EogtGD5084 under the control of Scer\GAL4tub.PU at 30[o]C is late pupal lethal. 94% of animals expressing EogtGD5084 under the control of Scer\GAL4Act.PU at 30[o]C hatch, while only 37% hatch if Dcr-2Scer\UAS.cDa is also present (to enhance RNAi).

Expression of EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa results in wing blistering specifically within the posterior compartment. This phenotype has almost complete penetrance at 27[o]C, and is not seen at 22.5[o]C. Eogtex10/+ enhances the phenotype, so that wing blistering with a penetrance of up to 30% is seen at 22.5[o]C.

Adults expressing EogtGD5084 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, enhanceable by dpylv1/dp[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, enhanceable by dpyolvR/dp[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, enhanceable by wb[+]/wbSF11

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, enhanceable by pyd3Lb5/Adcb-1

NOT Enhanced by
Statement
Reference

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-enhanceable by dpyv/e(dpyv)1

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-enhanceable by pio[+]/pio2R-16

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-enhanceable by pio[+]/pioMB03570

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-enhanceable by pot[+]/pote04564

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-enhanceable by mys1/mys[+]

Suppressed by
Statement
Reference

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by crbj1B5/crb[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by NAx-16/N[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by N[+]/NAx-E2

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by NAx-9/N[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Nspl-1/N[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Df(1)N-264-105/+

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by N[+]/N55e11

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Df(3R)ED6237/+

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Df(3R)ED5942/+

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Df(3L)ri-79c/+

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Df(2L)TE35BC-4/+

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Df(2R)BSC383/+

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by DeltaRevF10/Dl[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Ser[+]/SerRX106

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by PsnI2/Psn[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Psn227/Psn[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Su(H)[+]/Su(H)2

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by mam2/mam[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Df(1)N-81k1/+

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by N+t40

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by Dp(1;2)51b

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | temperature conditional by r9

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible by rcSa/In(1)r70b

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible by Dhod8

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible by r-lK2

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by r-le01755

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible | partially by e(r)G926

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible by Adcb-1

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, suppressible by Hsap\EOGTTub.PM

NOT suppressed by
Statement
Reference

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-suppressible by pio[+]/pio2R-16

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-suppressible by pio[+]/pioMB03570

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-suppressible by dpyv/e(dpyv)1

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-suppressible by pot[+]/pote04564

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-suppressible by mys1/mys[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has visible | heat sensitive phenotype, non-suppressible by Mmus\Pomgnt2Tub.PM

Other
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has wing blade posterior compartment | heat sensitive phenotype, non-enhanceable by pio[+]/pio2R-16

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has wing blade posterior compartment | heat sensitive phenotype, non-enhanceable by pio[+]/pioMB03570

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has wing blade posterior compartment | heat sensitive phenotype, non-enhanceable by pot[+]/pote04564

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has wing blade posterior compartment | heat sensitive phenotype, non-enhanceable by mys1/mys[+]

Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has wing blade posterior compartment | heat sensitive phenotype, non-suppressible by pot[+]/pote04564

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has wing blade posterior compartment | heat sensitive phenotype, non-suppressible by mys1/mys[+]

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has wing blade posterior compartment | heat sensitive phenotype, non-suppressible by pio[+]/pio2R-16

Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU has wing blade posterior compartment | heat sensitive phenotype, non-suppressible by pio[+]/pioMB03570

Additional Comments
Genetic Interactions
Statement
Reference

dplv1 and dpolvR each dominantly enhance the wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa, such that the phenotype is seen at 22.5[o]C.

dpv ; e(dpv)1 does not enhance or suppress the wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa.

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa is not affected if the flies are also heterozygous for either pio2R-16, pioMB03570, pote04564 or mys1.

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa is enhanced if the flies are also heterozygous for wbSF11.

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa is weakly but significantly suppressed if the flies are also heterozygous for crbj1B5.

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa is dominantly partially suppressed if the flies are also heterozygous for one of NAx-16, NAx-E2, NAx-9, Nspl-1, Df(1)N-264-105, N55e11, Df(3R)ED6237, Df(3R)ED5942, Df(3L)ri-79c, Df(2L)TE35BC-4, Df(2R)BSC383, Df(1)N-81k1, DlRevF10, SerRX106, PsnI2, Psn227, Su(H)2 or mam2.

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa is partially suppressed if the flies also carry N+t40 or Dp(1;2)51b.

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa is robustly suppressed at 27[o]C if the flies also carry r9. At 31[o]C, partial suppression is seen.

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa is robustly suppressed at 27[o]C if the flies also carry Dhod8, r-lK2 or b1.

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa is partially suppressed at 27[o]C if the flies also carry r-lK2 or e(r)G926.

In(1)r70b ; rcSa robustly suppresses the wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa at 27[o]C.

In(1)r70b ; rSu(b).cSa partially suppresses the wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa at 27[o]C.

b1 ; pyd3Lb5 enhances the wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa.

b1 ; pyd3+t3.8 ; pyd3Lb10 partially suppresses the wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa at 27[o]C.

Xenogenetic Interactions
Statement
Reference

Expression of Hsap\EOGTTub.PM completely suppresses the wing blistering phenotype seen in the posterior compartment of wings at 27[o]C in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa.

Expression of Mmus\Gtdc2Tub.PM fails to suppress the wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Linkouts
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG9867GD5084
EogtGD5084
Name Synonyms
Secondary FlyBase IDs
    References (7)