Open Close
General Information
Symbol
Dmel\Cp36GD6311
Species
D. melanogaster
Name
FlyBase ID
FBal0206613
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of an inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Eggs laid by flies expressing Cp36GD6311 under the control of Scer\GAL4c355 have a thin and fragile chorion, a highly dysmorphic dorsal appendages as well as malformed operculum, collar and aeropyle. The eggshell surface also lacks the typical follicular imprints. On the ultrastructural level, Cp36GD6311 knock-down leads to severely disrupted organization of the endochorion, while the exochorion, the inner chorionic layer and the vitelline membrane are not significantly affected. These eggs seem incapable of being fertilized by sperm as they fail to hatch and no post-zygotic mitotic nuclei are found in them. Expression of Cp36GD6311 driven by Scer\GAL4c522 or Scer\GAL4109C1 or Scer\GAL4109-28 does not affect the flies' fecundity as both the pupariation and eclosion rate is comparable to controls. And while with the first two drivers no structural defects in the laid eggs are observe, aged females (30-60 days old) females expressing Cp36GD6311 under the Scer\GAL4109-28 driver occasionally lay eggs with either extra (rather normal-looking) appendages or severely deformed and fused appendages, this is not seen in either age-matched controls or in younger knock-down flies.
Adults expressing Cp36GD6311 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Cp36GD6311
Name Synonyms
Secondary FlyBase IDs
    References (5)