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General Information
Symbol
Dmel\CrkGD8583
Species
D. melanogaster
Name
FlyBase ID
FBal0206688
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of CrkGD8583 under the control of Scer\GAL4elav-C155 leads to an increase in walking activity in males only. Males show fewer but longer sleep bouts.

Knockdown of Crk in astrocytes, through expression of CrkGD8583 under the control of Scer\GAL4alrm.PD, leads to a 20% reduction in astrocytic vacuole area compared to controls. These animals also exhibit a significant accumulation of brp[+] debris in the SOG and the abdominal region of the ventral nerve cord.

Expression of CrkGD8583 under the control of Scer\GAL4alrm.PD results in a mild suppression of mushroom body γ neuron pruning at 18 hours after pupal formation and a mild phenotype in adults.

The expression of CrkGD8583 under the control of Scer\GAL4srp.Hemo does not affect the competence of embryonic hemocytes of undertaking phagocytosis of apoptotic cells, as compared to controls.

Adults expressing CrkGD8583 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in missing adult indirect flight muscles.

Expression under the control of Scer\GAL4Mef2.PR results in morphologically wild-type myofibrils in the adult indirect flight muscles.

Expression under the control of Scer\GAL4Mef2.PR results in wild-type sarcomeres in the adult indirect flight muscles.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CrkGD8583
Name Synonyms
Secondary FlyBase IDs
    References (10)