The expression of DabKK102011
under the control of Scer\GAL4221
, in combination with Dicer-2 for efficient RNAi, results in third instar larval class I abdominal dorsal multidendritic ddaD and ddaE neurons exhibiting dendrite branch misrouting, as compared to controls; expression under the control of Scer\GAL4ppk.PG
, in combination with Dicer-2 for efficient RNAi, results in no obvious dendrite morphology defects in class IV abdominal dorsal multidendritic ddaC neurons, as compared to controls.
Expression under the control of Scer\GAL41407
results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.
Adults expressing DabGD4886
under the control of Scer\GAL4elav.PLu
(in the presence of Dcr-2Scer\UAS.cDa
to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR
can result in lethality by 7 days after eclosion or adult/pharate lethality.
Expression under the control of Scer\GAL4pnr-MD237
results in lethality (either before or at the pupal stage), depending on the insertion line used.