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General Information
Symbol
Dmel\Dcr-1GD11429
Species
D. melanogaster
Name
FlyBase ID
FBal0206827
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dcr-1RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Dcr-1GD11429 in the fat body under the control of Scer\GAL4ppl.PP increases the survival rates of both males and female adult flies subjected to nutrient starvation when compared to control flies.

Expression of Scer\GAL4en-e16E>Dcr-1GD11429 engenders an autonomous reduction in cell size the adult wing. As a consequence, the size of the adult wing is also reduced.

Co-expression of Dcr-1Scer\UAS.cDa restores cell and tissue size in wings expressing Scer\GAL4en-e16E>Dcr-1GD11429.

Dcr-1Q1147X heterozygosity enhances the wing size defects caused by the expression of Scer\GAL4en-e16E>Dcr-1GD11429. The viability of these flies is drastically reduced.

Wing disc cells expressing Scer\GAL4ptc-559.1>Dcr-1GD11429 show G[[1]]-S cell cycle delay.

Adults expressing Dcr-1GD11429 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression of Dcr-1GD11429 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) results in viable flies or complete lethality, depending on the particular P{GD11429} insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Dcr-1GD11429, Scer\GAL4en-e16E has size defective phenotype, suppressible by dap[+]/dap4

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of p53H159N.Scer\UAS.Ex suppresses the increase in survival rate in response to starvation in adult flies expressing Dcr-1GD11429 in the fat body under the control of Scer\GAL4ppl.PP.

Expression of Dcr-1GD11429 largely rescues the dorsal-ventral boundary defects seen when NdsRNA.P.Scer\UAS is expressed under the control of Scer\GAL4vg.int2.1.

Co-expression of CycEScer\UAS.cLa with Scer\GAL4en-e16E>Dcr-1GD11429 restores cell and wing size.

Heterozygous dap4 restores cell and wing size in animals expressing Scer\GAL4en-e16E>Dcr-1GD11429.

The tissue and cell size defects caused by Scer\GAL4en-e16E>Dcr-1GD11429 in adult wings are largely suppressed when dmScer\UAS.cZa is co-expressed.

The tissue and cell size defects caused by Scer\GAL4en-e16E>Dcr-1GD11429 in adult wings are largely suppressed when dmhs.PSA is co-expressed.

The tissue and cell size defects caused by Scer\GAL4en-e16E>Dcr-1GD11429 in adult wings are largely suppressed when dmαTub84B.PBb is co-expressed.

The cell size defects caused by Scer\GAL4en-e16E>Dcr-1GD11429 in adult wings are largely suppressed when mei-P26KK106754 is co-expressed.

banhs.PH expression can rescue the tissue and size defects caused by Scer\GAL4en-e16E>Dcr-1GD11429 in adult wings.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Dcr-1GD11429
Name Synonyms
Secondary FlyBase IDs
    References (10)